APCD1_HUMAN » Protein APCDD1

APCD1_HUMAN » Protein APCDD1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
APCD1_HUMAN » Protein APCDD1 » Adenomatosis polyposis coli down-regulated 1 protein;
Hydrophobic Thickness 23.2 ± 1.8 Å
Tilt Angle 0 ± 1°
ΔGtransfer -27.6 kcal/mol
ΔGfold -11.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 493-512 (491-513)
Pathways none
PDB none
OPM none
Complexes none
Interactions

LRP5, Complex: LRP5:APCD1, PubMed

Domains

AA: 51-282, Adenomatosis polyposis coli down-regulated 1

AA: 284-473, Adenomatosis polyposis coli down-regulated 1

UniProt annotation for APCD1_HUMAN » Protein APCDD1
FUNCTION: Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis.

SUBUNIT: Homodimer. Interacts with LRP5 and WNT3A.

TISSUE SPECIFICITY: Abundantly expressed in heart, pancreas, prostate and ovary. Moderately expressed in lung, liver, kidney, spleen, thymus, colon and peripheral lymphocytes. Abundantly expressed in both the epidermal and dermal compartments of the hair follicle. Present in scalp skin Highly expressed in the hair follicle dermal papilla, the matrix, and the hair shaft (at protein level).

INDUCTION: Target gene of the Wnt/Beta-catenin pathway, transcriptionally regulated by the CTNNB1/TF7L2 complex.

DISEASE: Hypotrichosis 1 (HYPT1) OMIM: A rare form of non- syndromic hereditary hypotrichosis without characteristic hair shaft anomalies. Affected individuals typically show normal hair at birth, but hair loss and thinning of the hair shaft start during early childhood and progress with age. mutations affecting the gene represented in this entry.

UniProt features for APCD1_HUMAN » Protein APCDD1
SIGNAL 1 26 Potential.
CHAIN 27 514 Protein APCDD1.
Amino Acid Sequence for APCD1_HUMAN » Protein APCDD1
MSWPRRLLLR YLFPALLLHG LGEGSALLHP DSRSHPRSLE KSAWRAFKES QCHHMLKHLH NGARITVQMP PTIEGHWVST GCEVRSGPEF ITRSYRFYHN NTFKAYQFYY GSNRCTNPTY TLIIRGKIRL RQASWIIRGG TEADYQLHNV QVICHTEAVA EKLGQQVNRT CPGFLADGGP WVQDVAYDLW REENGCECTK AVNFAMHELQ LIRVEKQYLH HNLDHLVEEL FLGDIHTDAT QRMFYRPSSY QPPLQNAKNH DHACIACRII YRSDEHHPPI LPPKADLTIG LHGEWVSQRC EVRPEVLFLT RHFIFHDNNN TWEGHYYHYS DPVCKHPTFS IYARGRYSRG VLSSRVMGGT EFVFKVNHMK VTPMDAATAS LLNVFNGNEC GAEGSWQVGI QQDVTHTNGC VALGIKLPHT EYEIFKMEQD ARGRYLLFNG QRPSDGSSPD RPEKRATSYQ MPLVQCASSS PRAEDLAEDS GSSLYGRAPG RHTWSLLLAA LACLVPLLHW NIRR