ANTR1_HUMAN » Anthrax toxin receptor 1

ANTR1_HUMAN » Anthrax toxin receptor 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ANTR1_HUMAN » Anthrax toxin receptor 1 » Tumor endothelial marker 8;
Hydrophobic Thickness 35.2 ± 1.6 Å
Tilt Angle 0 ± 2°
ΔGtransfer -50.5 kcal/mol
ΔGfold -27.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 319-343 (318-343)
Pathways none
PDB 3n2n (A/B...=38-220)
OPM none
Complexes

ANTR1:ANTR1_HUMAN

Interactions

ANTR1, Complex: Hexamer of anthrax toxin receptor, PDBID: 3N2N

B2CL1, Complex: B2CL1:ANTR1, PubMed

LRP6, Complex: ANTR1:LRP6, PubMed

Domains

AA: 44-214, PDBID: 3N2N, Subunit E, Seq Identity:100%, von Willebrand factor type A domain

AA: 218-319, PDBID: 3N2N, Subunit E, Seq Identity:100%, Anthrax receptor extracellular domain

AA: 396-488, Anthrax receptor C-terminus region

UniProt annotation for ANTR1_HUMAN » Anthrax toxin receptor 1
FUNCTION: Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.

SUBUNIT: Interacts with gelatin and type 1 collagen. Interacts with the actin cytoskeleton. Binds to the protective antigen (PA) of Bacillus anthracis. Binding does not occur in the presence of calcium.

TISSUE SPECIFICITY: Detected in umbilical vein endothelial cells (at protein level). Highly expressed in tumor endothelial cells.

INDUCTION: Up-regulated in cultured angiogenic umbilical vein endothelial cells.

DOMAIN: Binding to PA occurs through the VWA domain.

DISEASE: Hemangioma, capillary infantile (HCI) OMIM: A condition characterized by dull red, firm, dome-shaped hemangiomas, sharply demarcated from surrounding skin, usually presenting at birth or occurring within the first two or three months of life. They result from highly proliferative, localized growth of capillary endothelium and generally undergo regression and involution without scarring. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

DISEASE: GAPO syndrome (GAPO) OMIM: A disease characterized by growth retardation, alopecia, failure of tooth eruption, and progressive optic atrophy in some patients. mutations affecting the gene represented in this entry.

UniProt features for ANTR1_HUMAN » Anthrax toxin receptor 1
SIGNAL 1 32 Potential.
CHAIN 33 564 Anthrax toxin receptor 1.
DOMAIN 44 215 VWFA.
REGION 154 160 Interaction with PA.
DISULFID 39 220
Amino Acid Sequence for ANTR1_HUMAN » Anthrax toxin receptor 1
MATAERRALG IGFQWLSLAT LVLICAGQGG RREDGGPACY GGFDLYFILD KSGSVLHHWN EIYYFVEQLA HKFISPQLRM SFIVFSTRGT TLMKLTEDRE QIRQGLEELQ KVLPGGDTYM HEGFERASEQ IYYENRQGYR TASVIIALTD GELHEDLFFY SEREANRSRD LGAIVYCVGV KDFNETQLAR IADSKDHVFP VNDGFQALQG IIHSILKKSC IEILAAEPST ICAGESFQVV VRGNGFRHAR NVDRVLCSFK INDSVTLNEK PFSVEDTYLL CPAPILKEVG MKAALQVSMN DGLSFISSSV IITTTHCSDG SILAIALLIL FLLLALALLW WFWPLCCTVI IKEVPPPPAE ESEEEDDDGL PKKKWPTVDA SYYGGRGVGG IKRMEVRWGE KGSTEEGAKL EKAKNARVKM PEQEYEFPEP RNLNNNMRRP SSPRKWYSPI KGKLDALWVL LRKGYDRVSV MRPQPGDTGR CINFTRVKNN QPAKYPLNNA YHTSSPPPAP IYTPPPPAPH CPPPPPSAPT PPIPSPPSTL PPPPQAPPPN RAPPPSRPPP RPSV