ANPRC_HUMAN » Atrial natriuretic peptide receptor 3

ANPRC_HUMAN » Atrial natriuretic peptide receptor 3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ANPRC_HUMAN » Atrial natriuretic peptide receptor 3 » Atrial natriuretic peptide clearance receptor;Atrial natriuretic peptide receptor type C;ANP-C; ANPR-C; NPR-C;
Hydrophobic Thickness 29.2 ± 3.6 Å
Tilt Angle 7 ± 0°
ΔGtransfer -27.5 kcal/mol
ΔGfold -17.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 479-504 (479-508)
Pathways

Plant hormone signal transduction (KEGG)

PDB 1yk0 (A/B=1-480), 1yk1 (A/B=2-480), 1jdp (A/B=44-485), 1jdn (A=44-485)
OPM none
Complexes none
Interactions none
Domains

AA: 71-425, PDBID: 1JDN, Subunit A, Seq Identity:100%, Receptor family ligand binding region

UniProt annotation for ANPRC_HUMAN » Atrial natriuretic peptide receptor 3
FUNCTION: Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity.

SUBUNIT: Homodimer; disulfide-linked. Dimers can also be formed through the C-terminal cysteine of isoform 2.

MISCELLANEOUS: Has low affinity for peptide hormones in the absence of bound chloride.

UniProt features for ANPRC_HUMAN » Atrial natriuretic peptide receptor 3
SIGNAL 1 26 Potential.
CHAIN 27 541 Atrial natriuretic peptide receptor 3.
DISULFID 108 136
DISULFID 213 261
DISULFID 473 473 Interchain.
Amino Acid Sequence for ANPRC_HUMAN » Atrial natriuretic peptide receptor 3
MPSLLVLTFS PCVLLGWALL AGGTGGGGVG GGGGGAGIGG GRQEREALPP QKIEVLVLLP QDDSYLFSLT RVRPAIEYAL RSVEGNGTGR RLLPPGTRFQ VAYEDSDCGN RALFSLVDRV AAARGAKPDL ILGPVCEYAA APVARLASHW DLPMLSAGAL AAGFQHKDSE YSHLTRVAPA YAKMGEMMLA LFRHHHWSRA ALVYSDDKLE RNCYFTLEGV HEVFQEEGLH TSIYSFDETK DLDLEDIVRN IQASERVVIM CASSDTIRSI MLVAHRHGMT SGDYAFFNIE LFNSSSYGDG SWKRGDKHDF EAKQAYSSLQ TVTLLRTVKP EFEKFSMEVK SSVEKQGLNM EDYVNMFVEG FHDAILLYVL ALHEVLRAGY SKKDGGKIIQ QTWNRTFEGI AGQVSIDANG DRYGDFSVIA MTDVEAGTQE VIGDYFGKEG RFEMRPNVKY PWGPLKLRID ENRIVEHTNS SPCKSSGGLE ESAVTGIVVG ALLGAGLLMA FYFFRKKYRI TIERRTQQEE SNLGKHRELR EDSIRSHFSV A