ANPRB_HUMAN » Atrial natriuretic peptide receptor B

ANPRB_HUMAN » Atrial natriuretic peptide receptor B
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ANPRB_HUMAN » Atrial natriuretic peptide receptor B » ANP-B; ANPRB; GC-B;Guanylate cyclase B;NPR-B;Atrial natriuretic peptide B-type receptor;
Hydrophobic Thickness 34.4 ± 7.2 Å
Tilt Angle 49 ± 5°
ΔGtransfer -26.2 kcal/mol
ΔGfold -18.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 452-481 (452-485)
Pathways

Purine metabolism (KEGG)

Vascular smooth muscle contraction (KEGG)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 44-400, PDBID: 1DP4, Subunit A, Seq Identity:47%, Receptor family ligand binding region

AA: 518-786, PDBID: 4L68, Subunit B, Seq Identity:38%, Protein tyrosine kinase

AA: 852-1038, PDBID: 3UVJ, Subunit A, Seq Identity:49%, Adenylate and Guanylate cyclase catalytic domain

UniProt annotation for ANPRB_HUMAN » Atrial natriuretic peptide receptor B
FUNCTION: Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth.

CATALYTIC ACTIVITY: GTP = 3",5"-cyclic GMP + diphosphate.

DISEASE: Acromesomelic dysplasia, Maroteaux type (AMDM) OMIM: An autosomal recessive acromesomelic chondrodysplasia. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers). AMDM is characterized by axial skeletal involvement with wedging of vertebral bodies. In AMDM all skeletal elements are present but show abnormal rates of linear growth. by mutations affecting the gene represented in this entry.

DISEASE: Epiphyseal chondrodysplasia, Miura type (ECDM) OMIM: An overgrowth syndrome characterized by tall stature, long hands and feet with arachnodactyly, macrodactyly of the great toes, scoliosis, coxa valga and slipped capital femoral epiphysis. mutations affecting the gene represented in this entry.

UniProt features for ANPRB_HUMAN » Atrial natriuretic peptide receptor B
SIGNAL 1 22 Potential.
CHAIN 23 1047 Atrial natriuretic peptide receptor 2.
DOMAIN 513 786 Protein kinase.
DOMAIN 861 991 Guanylate cyclase.
DISULFID 75 101 By similarity.
DISULFID 439 439 Interchain (Probable).
DISULFID 448 448 Interchain (Probable).
Amino Acid Sequence for ANPRB_HUMAN » Atrial natriuretic peptide receptor B
MALPSLLLLV AALAGGVRPP GARNLTLAVV LPEHNLSYAW AWPRVGPAVA LAVEALGRAL PVDLRFVSSE LEGACSEYLA PLSAVDLKLY HDPDLLLGPG CVYPAASVAR FASHWRLPLL TAGAVASGFS AKNDHYRTLV RTGPSAPKLG EFVVTLHGHF NWTARAALLY LDARTDDRPH YFTIEGVFEA LQGSNLSVQH QVYAREPGGP EQATHFIRAN GRIVYICGPL EMLHEILLQA QRENLTNGDY VFFYLDVFGE SLRAGPTRAT GRPWQDNRTR EQAQALREAF QTVLVITYRE PPNPEYQEFQ NRLLIRARED FGVELGPSLM NLIAGCFYDG ILLYAEVLNE TIQEGGTRED GLRIVEKMQG RRYHGVTGLV VMDKNNDRET DFVLWAMGDL DSGDFQPAAH YSGAEKQIWW TGRPIPWVKG APPSDNPPCA FDLDDPSCDK TPLSTLAIVA LGTGITFIMF GVSSFLIFRK LMLEKELASM LWRIRWEELQ FGNSERYHKG AGSRLTLSLR GSSYGSLMTA HGKYQIFANT GHFKGNVVAI KHVNKKRIEL TRQVLFELKH MRDVQFNHLT RFIGACIDPP NICIVTEYCP RGSLQDILEN DSINLDWMFR YSLINDLVKG MAFLHNSIIS SHGSLKSSNC VVDSRFVLKI TDYGLASFRS TAEPDDSHAL YAKKLWTAPE LLSGNPLPTT GMQKADVYSF GIILQEIALR SGPFYLEGLD LSPKEIVQKV RNGQRPYFRP SIDRTQLNEE LVLLMERCWA QDPAERPDFG QIKGFIRRFN KEGGTSILDN LLLRMEQYAN NLEKLVEERT QAYLEEKRKA EALLYQILPH SVAEQLKRGE TVQAEAFDSV TIYFSDIVGF TALSAESTPM QVVTLLNDLY TCFDAIIDNF DVYKVETIGD AYMVVSGLPG RNGQRHAPEI ARMALALLDA VSSFRIRHRP HDQLRLRIGV HTGPVCAGVV GLKMPRYCLF GDTVNTASRM ESNGQALKIH VSSTTKDALD ELGCFQLELR GDVEMKGKGK MRTYWLLGER KGPPGLL