ANPRA_HUMAN » Atrial natriuretic peptide receptor A

ANPRA_HUMAN » Atrial natriuretic peptide receptor A
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ANPRA_HUMAN » Atrial natriuretic peptide receptor A » Atrial natriuretic peptide A-type receptor;ANPRA;ANP-A;NPR-A;Guanylate cyclase;GC-A;
Hydrophobic Thickness 36.8 ± 2.6 Å
Tilt Angle 0 ± 2°
ΔGtransfer -44.8 kcal/mol
ΔGfold -18.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 471-493 (471-501)
Pathways

Plant hormone signal transduction (KEGG)

Purine metabolism (KEGG)

Vascular smooth muscle contraction (KEGG)

PDB none
OPM none
Complexes

ANPRA:ANPRA_RAT

Interactions

ANPRA, Complex: Homodimer of hormone binding domain of the atrial natriuretic receptor, PDBID: 1DP4

NICA, Complex: ANPRA:NICA, PubMed

NICA, Complex: ANPRA:PSN1:NICA, PubMed

Domains

AA: 54-417, PDBID: 1DP4, Subunit A, Seq Identity:88%, Receptor family ligand binding region

AA: 542-801, PDBID: 4L68, Subunit B, Seq Identity:44%, Protein tyrosine kinase

AA: 867-1053, PDBID: 3UVJ, Subunit A, Seq Identity:48%, Adenylate and Guanylate cyclase catalytic domain

UniProt annotation for ANPRA_HUMAN » Atrial natriuretic peptide receptor A
FUNCTION: Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.

CATALYTIC ACTIVITY: GTP = 3",5"-cyclic GMP + diphosphate.

SUBUNIT: Homodimer.

UniProt features for ANPRA_HUMAN » Atrial natriuretic peptide receptor A
SIGNAL 1 32
CHAIN 33 1061 Atrial natriuretic peptide receptor 1.
DOMAIN 528 805 Protein kinase.
DOMAIN 876 1006 Guanylate cyclase.
DISULFID 92 118 By similarity.
DISULFID 196 245 By similarity.
DISULFID 455 464 By similarity.
Amino Acid Sequence for ANPRA_HUMAN » Atrial natriuretic peptide receptor A
MPGPRRPAGS RLRLLLLLLL PPLLLLLRGS HAGNLTVAVV LPLANTSYPW SWARVGPAVE LALAQVKARP DLLPGWTVRT VLGSSENALG VCSDTAAPLA AVDLKWEHNP AVFLGPGCVY AAAPVGRFTA HWRVPLLTAG APALGFGVKD EYALTTRAGP SYAKLGDFVA ALHRRLGWER QALMLYAYRP GDEEHCFFLV EGLFMRVRDR LNITVDHLEF AEDDLSHYTR LLRTMPRKGR VIYICSSPDA FRTLMLLALE AGLCGEDYVF FHLDIFGQSL QGGQGPAPRR PWERGDGQDV SARQAFQAAK IITYKDPDNP EYLEFLKQLK HLAYEQFNFT MEDGLVNTIP ASFHDGLLLY IQAVTETLAH GGTVTDGENI TQRMWNRSFQ GVTGYLKIDS SGDRETDFSL WDMDPENGAF RVVLNYNGTS QELVAVSGRK LNWPLGYPPP DIPKCGFDNE DPACNQDHLS TLEVLALVGS LSLLGILIVS FFIYRKMQLE KELASELWRV RWEDVEPSSL ERHLRSAGSR LTLSGRGSNY GSLLTTEGQF QVFAKTAYYK GNLVAVKRVN RKRIELTRKV LFELKHMRDV QNEHLTRFVG ACTDPPNICI LTEYCPRGSL QDILENESIT LDWMFRYSLT NDIVKGMLFL HNGAICSHGN LKSSNCVVDG RFVLKITDYG LESFRDLDPE QGHTVYAKKL WTAPELLRMA SPPVRGSQAG DVYSFGIILQ EIALRSGVFH VEGLDLSPKE IIERVTRGEQ PPFRPSLALQ SHLEELGLLM QRCWAEDPQE RPPFQQIRLT LRKFNRENSS NILDNLLSRM EQYANNLEEL VEERTQAYLE EKRKAEALLY QILPHSVAEQ LKRGETVQAE AFDSVTIYFS DIVGFTALSA ESTPMQVVTL LNDLYTCFDA VIDNFDVYKV ETIGDAYMVV SGLPVRNGRL HACEVARMAL ALLDAVRSFR IRHRPQEQLR LRIGIHTGPV CAGVVGLKMP RYCLFGDTVN TASRMESNGE ALKIHLSSET KAVLEEFGGF ELELRGDVEM KGKGKVRTYW LLGERGSSTR G