AMHR2_HUMAN » Anti-Muellerian hormone type-2 receptor

AMHR2_HUMAN » Anti-Muellerian hormone type-2 receptor
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
AMHR2_HUMAN » Anti-Muellerian hormone type-2 receptor » Anti-Muellerian hormone type II receptor;AMH type II receptor; MIS type II receptor;MISRII; MRII;
Hydrophobic Thickness 34.8 ± 4.8 Å
Tilt Angle 17 ± 7°
ΔGtransfer -30.0 kcal/mol
ΔGfold -30.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 145-169 (143-175)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

TGF-beta signaling pathway (KEGG)

PDB none
OPM none
Complexes none
Interactions

BMR1B, Complex: BMR1B:AMHR2, PubMed

TGFR1, Complex: TGFR1:AMHR2, PubMed

Domains

AA: 45-120, PDBID: 2HLQ, Subunit A, Seq Identity:26%, Activin types I and II receptor domain

AA: 205-505, PDBID: 3Q4T, Subunit B, Seq Identity:45%, Protein kinase domain

UniProt annotation for AMHR2_HUMAN » Anti-Muellerian hormone type-2 receptor
FUNCTION: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.

CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor- protein] phosphate.

DISEASE: Persistent Muellerian duct syndrome 2 (PMDS2) OMIM: A form of male pseudohermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males. Note=The disease is caused by mutations affecting the gene represented in this entry.

UniProt features for AMHR2_HUMAN » Anti-Muellerian hormone type-2 receptor
SIGNAL 1 17 Potential.
CHAIN 18 573 Anti-Muellerian hormone type-2 receptor.
DOMAIN 203 518 Protein kinase.
ACT_SITE 333 333 Proton acceptor (By similarity).
Amino Acid Sequence for AMHR2_HUMAN » Anti-Muellerian hormone type-2 receptor
MLGSLGLWAL LPTAVEAPPN RRTCVFFEAP GVRGSTKTLG ELLDTGTELP RAIRCLYSRC CFGIWNLTQD RAQVEMQGCR DSDEPGCESL HCDPSPRAHP SPGSTLFTCS CGTDFCNANY SHLPPPGSPG TPGSQGPQAA PGESIWMALV LLGLFLLLLL LLGSIILALL QRKNYRVRGE PVPEPRPDSG RDWSVELQEL PELCFSQVIR EGGHAVVWAG QLQGKLVAIK AFPPRSVAQF QAERALYELP GLQHDHIVRF ITASRGGPGR LLSGPLLVLE LHPKGSLCHY LTQYTSDWGS SLRMALSLAQ GLAFLHEERW QNGQYKPGIA HRDLSSQNVL IREDGSCAIG DLGLALVLPG LTQPPAWTPT QPQGPAAIME AGTQRYMAPE LLDKTLDLQD WGMALRRADI YSLALLLWEI LSRCPDLRPD SSPPPFQLAY EAELGNTPTS DELWALAVQE RRRPYIPSTW RCFATDPDGL RELLEDCWDA DPEARLTAEC VQQRLAALAH PQESHPFPES CPRGCPPLCP EDCTSIPAPT ILPCRPQRSA CHFSVQQGPC SRNPQPACTL SPV