AMGO3_HUMAN » Amphoterin-induced protein 3

AMGO3_HUMAN » Amphoterin-induced protein 3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
AMGO3_HUMAN » Amphoterin-induced protein 3 » AMIGO-3;Alivin-3;
Hydrophobic Thickness 30.8 ± 1.6 Å
Tilt Angle 1 ± 0°
ΔGtransfer -47.3 kcal/mol
ΔGfold -14.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 381-404 (378-404)
Pathways none
PDB none
OPM none
Complexes none
Interactions

AMGO1, Complex: AMGO3:AMGO1, PubMed

AMGO2, Complex: AMGO3:AMGO2, PubMed

Domains

AA: 61-97, PDBID: 3WPF, Subunit A, Seq Identity:62%, Leucine rich repeat

AA: 85-145, PDBID: 4CNC, Subunit B, Seq Identity:41%, Leucine rich repeat

AA: 134-195, PDBID: 4P8S, Subunit A, Seq Identity:43%, Leucine rich repeat

UniProt annotation for AMGO3_HUMAN » Amphoterin-induced protein 3
FUNCTION: May mediate heterophilic cell-cell interaction. May contribute to signal transduction through its intracellular domain (By similarity).

SUBUNIT: Binds AMIGO1 or AMIGO2.

UniProt features for AMGO3_HUMAN » Amphoterin-induced protein 3
SIGNAL 1 19 Potential.
CHAIN 20 504 Amphoterin-induced protein 3.
DOMAIN 25 61 LRRNT.
REPEAT 62 83 LRR 1.
REPEAT 86 107 LRR 2.
REPEAT 110 133 LRR 3.
REPEAT 134 155 LRR 4.
REPEAT 158 178 LRR 5.
REPEAT 184 207 LRR 6.
DOMAIN 219 275 LRRCT.
DOMAIN 277 370 Ig-like C2-type.
DISULFID 34 40 By similarity.
DISULFID 38 47 By similarity.
DISULFID 223 251 By similarity.
DISULFID 225 273 By similarity.
DISULFID 300 352 By similarity.
Amino Acid Sequence for AMGO3_HUMAN » Amphoterin-induced protein 3
MTWLVLLGTL LCMLRVGLGT PDSEGFPPRA LHNCPYKCIC AADLLSCTGL GLQDVPAELP AATADLDLSH NALQRLRPGW LAPLFQLRAL HLDHNELDAL GRGVFVNASG LRLLDLSSNT LRALGRHDLD GLGALEKLLL FNNRLVHLDE HAFHGLRALS HLYLGCNELA SFSFDHLHGL SATHLLTLDL SSNRLGHISV PELAALPAFL KNGLYLHNNP LPCDCRLYHL LQRWHQRGLS AVRDFAREYV CLAFKVPASR VRFFQHSRVF ENCSSAPALG LERPEEHLYA LVGRSLRLYC NTSVPAMRIA WVSPQQELLR APGSRDGSIA VLADGSLAIG NVQEQHAGLF VCLATGPRLH HNQTHEYNVS VHFPRPEPEA FNTGFTTLLG CAVGLVLVLL YLFAPPCRCC RRACRCRRWP QTPSPLQELS AQSSVLSTTP PDAPSRKASV HKHVVFLEPG RRGLNGRVQL AVAEEFDLYN PGGLQLKAGS ESASSIGSEG PMTT