AMGO2_HUMAN » Amphoterin-induced protein 2

AMGO2_HUMAN » Amphoterin-induced protein 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
AMGO2_HUMAN » Amphoterin-induced protein 2 » AMIGO-2;Alivin-1;Differentially expressed in gastric adenocarcinomas;DEGA;
Hydrophobic Thickness 33.6 ± 1.6 Å
Tilt Angle 0 ± 0°
ΔGtransfer -46.2 kcal/mol
ΔGfold -17.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 396-420 (392-420)
Pathways none
PDB none
OPM none
Complexes none
Interactions

AMGO1, Complex: AMGO1:AMGO2, PubMed

AMGO3, Complex: AMGO3:AMGO2, PubMed

Domains

AA: 93-153, PDBID: 4U7L, Subunit A, Seq Identity:41%, Leucine rich repeat

AA: 132-177, PDBID: 3WPB, Subunit A, Seq Identity:52%, Leucine rich repeat

AA: 142-204, PDBID: 4J0M, Subunit A, Seq Identity:38%, Leucine rich repeat

AA: 298-371, PDBID: 3P3Y, Subunit A, Seq Identity:34%, Immunoglobulin domain

UniProt annotation for AMGO2_HUMAN » Amphoterin-induced protein 2
FUNCTION: Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.

SUBUNIT: Binds itself as well as AMIGO1 and AMIGO3.

TISSUE SPECIFICITY: Highest levels in breast, ovary, cervix, and uterus. Lower levels in lung, colon, and rectum. Differentially expressed in 56% of thyroid, 57% of pancreatic and 45% of stomach cancers.

UniProt features for AMGO2_HUMAN » Amphoterin-induced protein 2
SIGNAL 1 39 Potential.
CHAIN 40 522 Amphoterin-induced protein 2.
DOMAIN 40 68 LRRNT.
REPEAT 69 90 LRR 1.
REPEAT 94 115 LRR 2.
REPEAT 118 139 LRR 3.
REPEAT 142 163 LRR 4.
REPEAT 166 187 LRR 5.
REPEAT 193 214 LRR 6.
DOMAIN 228 284 LRRCT.
DOMAIN 289 379 Ig-like C2-type.
DISULFID 41 47 By similarity.
DISULFID 45 54 By similarity.
DISULFID 232 260 By similarity.
DISULFID 234 282 By similarity.
DISULFID 310 363 By similarity.
Amino Acid Sequence for AMGO2_HUMAN » Amphoterin-induced protein 2
MSLRVHTLPT LLGAVVRPGC RELLCLLMIT VTVGPGASGV CPTACICATD IVSCTNKNLS KVPGNLFRLI KRLDLSYNRI GLLDSEWIPV SFAKLNTLIL RHNNITSIST GSFSTTPNLK CLDLSSNKLK TVKNAVFQEL KVLEVLLLYN NHISYLDPSA FGGLSQLQKL YLSGNFLTQF PMDLYVGRFK LAELMFLDVS YNRIPSMPMH HINLVPGKQL RGIYLHGNPF VCDCSLYSLL VFWYRRHFSS VMDFKNDYTC RLWSDSRHSR QVLLLQDSFM NCSDSIINGS FRALGFIHEA QVGERLMVHC DSKTGNANTD FIWVGPDNRL LEPDKEMENF YVFHNGSLVI ESPRFEDAGV YSCIAMNKQR LLNETVDVTI NVSNFTVSRS HAHEAFNTAF TTLAACVASI VLVLLYLYLT PCPCKCKTKR QKNMLHQSNA HSSILSPGPA SDASADERKA GAGKRVVFLE PLKDTAAGQN GKVRLFPSEA VIAEGILKST RGKSDSDSVN SVFSDTPFVA ST