AMGO1_HUMAN » Amphoterin-induced protein 1

AMGO1_HUMAN » Amphoterin-induced protein 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
AMGO1_HUMAN » Amphoterin-induced protein 1 » AMIGO-1;Alivin-2;
Hydrophobic Thickness 27.2 ± 1.6 Å
Tilt Angle 0 ± 0°
ΔGtransfer -37.6 kcal/mol
ΔGfold -14.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 372-394 (372-394)
Pathways none
PDB none
OPM none
Complexes

AMGO1:AMGO1_MOUSE

Interactions

AMGO1, Complex: Homodimer of amphoterin-induced protein, PDBID: 2XOT

AMGO2, Complex: AMGO1:AMGO2, PubMed

AMGO3, Complex: AMGO3:AMGO1, PubMed

Domains

AA: 62-122, PDBID: 2XOT, Subunit A, Seq Identity:95%, Leucine rich repeat

AA: 110-170, PDBID: 2XOT, Subunit A, Seq Identity:88%, Leucine rich repeat

AA: 272-358, PDBID: 2XOT, Subunit A, Seq Identity:82%, Immunoglobulin I-set domain

UniProt annotation for AMGO1_HUMAN » Amphoterin-induced protein 1
FUNCTION: Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain (By similarity).

SUBUNIT: Homodimer, and heterodimer with AMIGO2 and AMIGO3.

DOMAIN: The LRR repeat region mediates homodimerization.

UniProt features for AMGO1_HUMAN » Amphoterin-induced protein 1
SIGNAL 1 27 Potential.
CHAIN 28 493 Amphoterin-induced protein 1.
DOMAIN 28 61 LRRNT.
REPEAT 62 83 LRR 1.
REPEAT 87 108 LRR 2.
REPEAT 111 132 LRR 3.
REPEAT 135 156 LRR 4.
REPEAT 159 179 LRR 5.
REPEAT 186 206 LRR 6.
DOMAIN 221 272 LRRCT.
DOMAIN 269 353 Ig-like C2-type.
DISULFID 34 40 By similarity.
DISULFID 38 47 By similarity.
DISULFID 225 253 By similarity.
DISULFID 227 270 By similarity.
DISULFID 290 341 By similarity.
Amino Acid Sequence for AMGO1_HUMAN » Amphoterin-induced protein 1
MHPHRDPRGL WLLLPSLSLL LFEVARAGRA VVSCPAACLC ASNILSCSKQ QLPNVPHSLP SYTALLDLSH NNLSRLRAEW TPTRLTQLHS LLLSHNHLNF ISSEAFSPVP NLRYLDLSSN QLRTLDEFLF SDLQVLEVLL LYNNHIMAVD RCAFDDMAQL QKLYLSQNQI SRFPLELVKE GAKLPKLTLL DLSSNKLKNL PLPDLQKLPA WIKNGLYLHN NPLNCDCELY QLFSHWQYRQ LSSVMDFQED LYCMNSKKLH NVFNLSFLNC GEYKERAWEA HLGDTLIIKC DTKQQGMTKV WVTPSNERVL DEVTNGTVSV SKDGSLLFQQ VQVEDGGVYT CYAMGETFNE TLSVELKVHN FTLHGHHDTL NTAYTTLVGC ILSVVLVLIY LYLTPCRCWC RGVEKPSSHQ GDSLSSSMLS TTPNHDPMAG GDKDDGFDRR VAFLEPAGPG QGQNGKLKPG NTLPVPEATG KGQRRMSDPE SVSSVFSDTP IVV