AJAP1_HUMAN » Adherens junction-associated protein 1

AJAP1_HUMAN » Adherens junction-associated protein 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
AJAP1_HUMAN » Adherens junction-associated protein 1 » Membrane protein shrew-1;
Hydrophobic Thickness 36.4 ± 1.8 Å
Tilt Angle 6 ± 3°
ΔGtransfer -49.2 kcal/mol
ΔGfold -22.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 278-303 (274-304)
Pathways none
PDB none
OPM none
Complexes none
Interactions

CADH1, Complex: AJAP1:CADH1, PubMed

CADH1, Complex: CTNB1:CADH1:AJAP1, PubMed

Domains

AA: 181-388, AJAP1/PANP C-terminus

UniProt annotation for AJAP1_HUMAN » Adherens junction-associated protein 1
FUNCTION: Plays a role in cell adhesion and cell migration.

SUBUNIT: Forms a complex with CDH1 and CTNNB1; interacts directly with CTNNB1. Interacts with AP1M2 and BSG/CD147.

TISSUE SPECIFICITY: Expressed in uterus and pancreas (at protein level).

UniProt features for AJAP1_HUMAN » Adherens junction-associated protein 1
CHAIN 1 411 Adherens junction-associated protein 1.
REGION 303 411 Targeting signals.
Amino Acid Sequence for AJAP1_HUMAN » Adherens junction-associated protein 1
MWIQQLLGLS SMSIRWPGRP LGSHAWILIA MFQLAVDLPA CEALGPGPEF WLLPRSPPRP PRLWSFRSGQ PARVPAPVWS PRPPRVERIH GQMQMPRARR AHRPRDQAAA LVPKAGLAKP PAAAKSSPSL ASSSSSSSSA VAGGAPEQQA LLRRGKRHLQ GDGLSSFDSR GSRPTTETEF IAWGPTGDEE ALESNTFPGV YGPTTVSILQ TRKTTVAATT TTTTTATPMT LQTKGFTESL DPRRRIPGGV STTEPSTSPS NNGEVTQPPR ILGEASGLAV HQIITITVSL IMVIAALITT LVLKNCCAQS GNTRRNSHQR KTNQQEESCQ NLTDFPSARV PSSLDIFTAY NETLQCSHEC VRASVPVYTD ETLHSTTGEY KSTFNGNRPS SSDRHLIPVA FVSEKWFEIS C