AEGP_HUMAN » Apical endosomal glycoprotein

AEGP_HUMAN » Apical endosomal glycoprotein
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Topology in Endosome membrane
Topologyendosome lumenal side
cytoplasmic side
AEGP_HUMAN » Apical endosomal glycoprotein » MAM domain-containing protein 4;
Hydrophobic Thickness 28.4 ± 2.4 Å
Tilt Angle 0 ± 4°
ΔGtransfer -35.8 kcal/mol
ΔGfold -15.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 1151-1173 (1151-1180)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 66-230, PDBID: 4GWM, Subunit A, Seq Identity:19%, MAM domain, meprin/A5/mu

AA: 227-265, PDBID: 1D2J, Subunit A, Seq Identity:39%, Low-density lipoprotein receptor domain class A

AA: 271-424, PDBID: 4GWM, Subunit A, Seq Identity:21%, MAM domain, meprin/A5/mu

AA: 493-643, PDBID: 4GWM, Subunit A, Seq Identity:22%, MAM domain, meprin/A5/mu

AA: 656-808, PDBID: 2C9A, Subunit A, Seq Identity:30%, MAM domain, meprin/A5/mu

AA: 813-968, PDBID: 4GWM, Subunit A, Seq Identity:27%, MAM domain, meprin/A5/mu

AA: 973-1137, PDBID: 2C9A, Subunit A, Seq Identity:21%, MAM domain, meprin/A5/mu

UniProt annotation for AEGP_HUMAN » Apical endosomal glycoprotein
FUNCTION: Probably involved in the sorting and selective transport of receptors and ligands across polarized epithelia.
UniProt features for AEGP_HUMAN » Apical endosomal glycoprotein
SIGNAL 1 22 Potential.
CHAIN 23 1216 Apical endosomal glycoprotein.
DOMAIN 26 53 LDL-receptor class A 1; truncated.
DOMAIN 64 222 MAM 1.
DOMAIN 228 266 LDL-receptor class A 2.
DOMAIN 269 425 MAM 2.
DOMAIN 456 491 LDL-receptor class A 3.
DOMAIN 491 644 MAM 3.
DOMAIN 654 809 MAM 4.
DOMAIN 811 969 MAM 5.
DOMAIN 971 1138 MAM 6.
DISULFID 229 241 By similarity.
DISULFID 236 254 By similarity.
DISULFID 248 265 By similarity.
DISULFID 457 468 By similarity.
DISULFID 464 481 By similarity.
DISULFID 475 490 By similarity.
Amino Acid Sequence for AEGP_HUMAN » Apical endosomal glycoprotein
MPLSSHLLPA LVLFLAGSSG WAWVPNHCRS PGQAVCNFVC DCRDCSDEAQ CGYHGASPTL GAPFACDFEQ DPCGWRDIST SGYSWLRDRA GAALEGPGPH SDHTLGTDLG WYMAVGTHRG KEASTAALRS PTLREAASSC KLRLWYHAAS GDVAELRVEL THGAETLTLW QSTGPWGPGW QELAVTTGRI RGDFRVTFSA TRNATHRGAV ALDDLEFWDC GLPTPQANCP PGHHHCQNKV CVEPQQLCDG EDNCGDLSDE NPLTCGRHIA TDFETGLGPW NRSEGWSRNH RAGGPERPSW PRRDHSRNSA QGSFLVSVAE PGTPAILSSP EFQASGTSNC SLVFYQYLSG SEAGCLQLFL QTLGPGAPRA PVLLRRRRGE LGTAWVRDRV DIQSAYPFQI LLAGQTGPGG VVGLDDLILS DHCRPVSEVS TLQPLPPGPR APAPQPLPPS SRLQDSCKQG HLACGDLCVP PEQLCDFEEQ CAGGEDEQAC GTTDFESPEA GGWEDASVGR LQWRRVSAQE SQGSSAAAAG HFLSLQRAWG QLGAEARVLT PLLGPSGPSC ELHLAYYLQS QPRGFLALVV VDNGSRELAW QALSSSAGIW KVDKVLLGAR RRPFRLEFVG LVDLDGPDQQ GAGVDNVTLR DCSPTVTTER DREVSCNFER DTCSWYPGHL SDTHWRWVES RGPDHDHTTG QGHFVLLDPT DPLAWGHSAH LLSRPQVPAA PTECLSFWYH LHGPQIGTLR LAMRREGEET HLWSRSGTQG NRWHEAWATL SHQPGSHAQY QLLFEGLRDG YHGTMALDDV AVRPGPCWAP NYCSFEDSDC GFSPGGQGLW RRQANASGHA AWGPPTDHTT ETAQGHYMVV DTSPDALPRG QTASLTSKEH RPLAQPACLT FWYHGSLRSP GTLRVYLEER GRHQVLSLSA HGGLAWRLGS MDVQAERAWR VVFEAVAAGV AHSYVALDDL LLQDGPCPQP GSCDFESGLC GWSHLAWPGL GGYSWDWGGG ATPSRYPQPP VDHTLGTEAG HFAFFETGVL GPGGRAAWLR SEPLPATPAS CLRFWYHMGF PEHFYKGELK VLLHSAQGQL AVWGAGGHRR HQWLEAQVEV ASAKEFQIVF EATLGGQPAL GPIALDDVEY LAGQHCQQPA PSPGNTAAPG SVPAVVGSAL LLLMLLVLLG LGGRRWLQKK GSCPFQSNTE ATAPGFDNIL FNADGVTLPA SVTSDP