ADCK4_HUMAN » AarF domain-containing protein kinase 4

ADCK4_HUMAN » AarF domain-containing protein kinase 4
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Topology in Mitochondrial inner membrane
Topologyintermembrane space
mitochondrial matrix side
ADCK4_HUMAN » AarF domain-containing protein kinase 4 »
Hydrophobic Thickness 28.4 ± 1.8 Å
Tilt Angle 2 ± 1°
ΔGtransfer -24.1 kcal/mol
ΔGfold -7.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 92-113 (85-115)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 197-313, PDBID: 4PED, Subunit A, Seq Identity:61%, ABC1 family

UniProt annotation for ADCK4_HUMAN » AarF domain-containing protein kinase 4
FUNCTION: May play a role in CoQ10 (COQ10A and/or COQ10B) biosynthesis, which is required for podocyte migration.

SUBUNIT: Homodimer; homodimerizes via its transmembrane region (PubMed). Interacts with COQ6 and COQ7 (PubMed).

TISSUE SPECIFICITY: Widely expressed, including renal podocytes.

DISEASE: Nephrotic syndrome 9 (NPHS9) OMIM: A form of nephrotic syndrome, a renal disease clinically characterized by progressive renal failure, severe proteinuria, hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show focal segmental glomerulosclerosis. disease is caused by mutations affecting the gene represented in this entry.

UniProt features for ADCK4_HUMAN » AarF domain-containing protein kinase 4
CHAIN 1 544 AarF domain-containing protein kinase 4.
DOMAIN 191 423 Protein kinase.
Amino Acid Sequence for ADCK4_HUMAN » AarF domain-containing protein kinase 4
MWLKVGGLLR GTGGQLGQTV GWPCGALGPG PHRWGPCGGS WAQKFYQDGP GRGLGEEDIR RAREARPRKT PRPQLSDRSR ERKVPASRIS RLANFGGLAV GLGLGVLAEM AKKSMPGGRL QSEGGSGLDS SPFLSEANAE RIVQTLCTVR GAALKVGQML SIQDNSFISP QLQHIFERVR QSADFMPRWQ MLRVLEEELG RDWQAKVASL EEVPFAAASI GQVHQGLLRD GTEVAVKIQY PGIAQSIQSD VQNLLAVLKM SAALPAGLFA EQSLQALQQE LAWECDYRRE AACAQNFRQL LANDPFFRVP AVVKELCTTR VLGMELAGGV PLDQCQGLSQ DLRNQICFQL LTLCLRELFE FRFMQTDPNW ANFLYDASSH QVTLLDFGAS REFGTEFTDH YIEVVKAAAD GDRDCVLQKS RDLKFLTGFE TKAFSDAHVE AVMILGEPFA TQGPYDFGSG ETARRIQDLI PVLLRHRLCP PPEETYALHR KLAGAFLACA HLRAHIACRD LFQDTYHRYW ASRQPDAATA GSLPTKGDSW VDPS