ACV1C_HUMAN » Activin receptor type-1C

ACV1C_HUMAN » Activin receptor type-1C
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ACV1C_HUMAN » Activin receptor type-1C » Activin receptor type IC;ACTR-IC; Activin receptor-like kinase 7;ALK-7;
Hydrophobic Thickness 31.2 ± 3.2 Å
Tilt Angle 0 ± 2°
ΔGtransfer -34.7 kcal/mol
ΔGfold -19.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 111-135 (111-147)
Pathways

Developmental Biology (Reactome)

Signal Transduction (Reactome)

TGF-beta signaling pathway (KEGG)

PDB none
OPM none
Complexes none
Interactions

ACV1B, Complex: ACV1C:GDF11:ACV1B:AVR2B:TGFR1, PubMed

Domains

AA: 166-193, PDBID: 1B6C, Subunit B, Seq Identity:93%, Transforming growth factor beta type I GS-motif

AA: 195-482, PDBID: 3MY0, Subunit H, Seq Identity:78%, Protein tyrosine kinase

UniProt annotation for ACV1C_HUMAN » Activin receptor type-1C
FUNCTION: Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.

CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor- protein] phosphate.

SUBUNIT: Binds the type 2 receptor protein ACVR2A.

TISSUE SPECIFICITY: Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy.

UniProt features for ACV1C_HUMAN » Activin receptor type-1C
SIGNAL 1 20 Potential.
CHAIN 21 493 Activin receptor type-1C.
DOMAIN 165 194 GS.
DOMAIN 195 485 Protein kinase.
ACT_SITE 323 323 Proton acceptor (By similarity).
Amino Acid Sequence for ACV1C_HUMAN » Activin receptor type-1C
MTRALCSALR QALLLLAAAA ELSPGLKCVC LLCDSSNFTC QTEGACWASV MLTNGKEQVI KSCVSLPELN AQVFCHSSNN VTKTECCFTD FCNNITLHLP TASPNAPKLG PMELAIIITV PVCLLSIAAM LTVWACQGRQ CSYRKKKRPN VEEPLSECNL VNAGKTLKDL IYDVTASGSG SGLPLLVQRT IARTIVLQEI VGKGRFGEVW HGRWCGEDVA VKIFSSRDER SWFREAEIYQ TVMLRHENIL GFIAADNKDN GTWTQLWLVS EYHEQGSLYD YLNRNIVTVA GMIKLALSIA SGLAHLHMEI VGTQGKPAIA HRDIKSKNIL VKKCETCAIA DLGLAVKHDS ILNTIDIPQN PKVGTKRYMA PEMLDDTMNV NIFESFKRAD IYSVGLVYWE IARRCSVGGI VEEYQLPYYD MVPSDPSIEE MRKVVCDQKF RPSIPNQWQS CEALRVMGRI MRECWYANGA ARLTALRIKK TISQLCVKED CKA