1C06_HUMAN » HLA class I histocompatibility antigen, Cw-6 alpha chain

1C06_HUMAN » HLA class I histocompatibility antigen, Cw-6 alpha chain
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
1C06_HUMAN » HLA class I histocompatibility antigen, Cw-6 alpha chain » MHC class I antigen Cw*6;
Hydrophobic Thickness 37.2 ± 2.4 Å
Tilt Angle 0 ± 0°
ΔGtransfer -50.1 kcal/mol
ΔGfold -25.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 305-334 (305-336)
Pathways

Allograft rejection (KEGG)

Antigen processing and presentation (KEGG)

Autoimmune thyroid disease (KEGG)

Cell adhesion molecules (KEGG)

Endocytosis (KEGG)

Epstein-Barr virus infection (KEGG)

Graft-versus-host disease (KEGG)

Herpes simplex infection (KEGG)

HTLV-I infection (KEGG)

Immune System (Reactome)

Natural killer cell mediated cytotoxicity (KEGG)

Phagosome (KEGG)

Type I diabetes mellitus (KEGG)

Viral carcinogenesis (KEGG)

Viral myocarditis (KEGG)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 25-203, PDBID: 1IM9, Subunit A, Seq Identity:93%, Class I Histocompatibility antigen, domains alpha 1 and 2

AA: 209-290, PDBID: 4NT6, Subunit A, Seq Identity:100%, Immunoglobulin C1-set domain

AA: 338-365, PDBID: 4EMZ, Subunit D, Seq Identity:79%, MHC_I C-terminus

UniProt annotation for 1C06_HUMAN » HLA class I histocompatibility antigen, Cw-6 alpha chain
FUNCTION: Involved in the presentation of foreign antigens to the immune system.

SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).

DISEASE: Psoriasis 1 (PSORS1) OMIM: A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

UniProt features for 1C06_HUMAN » HLA class I histocompatibility antigen, Cw-6 alpha chain
SIGNAL 1 24
CHAIN 25 366 HLA class I histocompatibility antigen, Cw-6 alpha chain.
DOMAIN 209 297 Ig-like C1-type.
REGION 25 114 Alpha-1.
REGION 115 206 Alpha-2.
REGION 207 298 Alpha-3.
REGION 299 308 Connecting peptide.
DISULFID 125 188 By similarity.
DISULFID 227 283 By similarity.
Amino Acid Sequence for 1C06_HUMAN » HLA class I histocompatibility antigen, Cw-6 alpha chain
MRVMAPRTLI LLLSGALALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQADRV NLRKLRGYYN QSEDGSHTLQ WMYGCDLGPD GRLLRGYDQS AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAAREAEQW RAYLEGTCVE WLRRYLENGK ETLQRAEHPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP SSQPTIPIVG IVAGLAVLAV LAVLGAVMAV VMCRRKSSGG KGGSCSQAAS SNSAQGSDES LIACKA