1C04_HUMAN » HLA class I histocompatibility antigen, Cw-4 alpha chain

1C04_HUMAN » HLA class I histocompatibility antigen, Cw-4 alpha chain
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
1C04_HUMAN » HLA class I histocompatibility antigen, Cw-4 alpha chain » MHC class I antigen Cw*4;
Hydrophobic Thickness 39.6 ± 2.4 Å
Tilt Angle 0 ± 0°
ΔGtransfer -49.6 kcal/mol
ΔGfold -24.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 305-334 (305-336)
Pathways

Allograft rejection (KEGG)

Antigen processing and presentation (KEGG)

Autoimmune thyroid disease (KEGG)

Cell adhesion molecules (KEGG)

Endocytosis (KEGG)

Epstein-Barr virus infection (KEGG)

Graft-versus-host disease (KEGG)

Herpes simplex infection (KEGG)

HTLV-I infection (KEGG)

Immune System (Reactome)

Natural killer cell mediated cytotoxicity (KEGG)

Phagosome (KEGG)

Type I diabetes mellitus (KEGG)

Viral carcinogenesis (KEGG)

Viral myocarditis (KEGG)

PDB 1im9 (A/E=25-299), 1qqd (A=26-298)
OPM none
Complexes

KI2L1:1C04:B2MG_HUMAN

Interactions

1B07, Complex: 1B07:1C04, PubMed

1B08, Complex: 1B08:1C04, PubMed

KI2L1, Complex: 1C04:B2MG:KI2L1, PDBID: 1im9, PubMed

Domains

AA: 25-203, PDBID: 1IM9, Subunit A, Seq Identity:100%, Class I Histocompatibility antigen, domains alpha 1 and 2

AA: 209-290, PDBID: 1EFX, Subunit A, Seq Identity:100%, Immunoglobulin C1-set domain

AA: 338-365, PDBID: 4EMZ, Subunit D, Seq Identity:79%, MHC_I C-terminus

UniProt annotation for 1C04_HUMAN » HLA class I histocompatibility antigen, Cw-4 alpha chain
FUNCTION: Involved in the presentation of foreign antigens to the immune system.

SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity). Interacts with HTLV-1 p12I accessory protein.

UniProt features for 1C04_HUMAN » HLA class I histocompatibility antigen, Cw-4 alpha chain
SIGNAL 1 24
CHAIN 25 366 HLA class I histocompatibility antigen, Cw-4 alpha chain.
DOMAIN 209 297 Ig-like C1-type.
REGION 25 114 Alpha-1.
REGION 115 206 Alpha-2.
REGION 207 298 Alpha-3.
REGION 299 308 Connecting peptide.
DISULFID 125 188 By similarity.
DISULFID 227 283 By similarity.
Amino Acid Sequence for 1C04_HUMAN » HLA class I histocompatibility antigen, Cw-4 alpha chain
MRVMAPRTLI LLLSGALALT ETWAGSHSMR YFSTSVSWPG RGEPRFIAVG YVDDTQFVRF DSDAASPRGE PREPWVEQEG PEYWDRETQK YKRQAQADRV NLRKLRGYYN QSEDGSHTLQ RMFGCDLGPD GRLLRGYNQF AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAAREAEQR RAYLEGTCVE WLRRYLENGK ETLQRAEHPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQWDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWKP SSQPTIPIVG IVAGLAVLAV LAVLGAMVAV VMCRRKSSGG KGGSCSQAAS SNSAQGSDES LIACKA