![]() | extracellular side |
cytoplasmic side |
1B59_HUMAN » HLA class I histocompatibility antigen, B-59 alpha chain » MHC class I antigen B*59; | |
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Hydrophobic Thickness | 36.0 ± 3.6 Å |
Tilt Angle | 29 ± 0° |
ΔGtransfer | -27.9 kcal/mol |
ΔGfold | -23.4 kcal/mol |
Links | UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome |
Topology | Out |
TM Segments | 305-331 (305-336) |
Pathways | Allograft rejection (KEGG) Antigen processing and presentation (KEGG) Autoimmune thyroid disease (KEGG) Cell adhesion molecules (KEGG) Endocytosis (KEGG) Epstein-Barr virus infection (KEGG) Graft-versus-host disease (KEGG) Herpes simplex infection (KEGG) HTLV-I infection (KEGG) Immune System (Reactome) Natural killer cell mediated cytotoxicity (KEGG) Phagosome (KEGG) Type I diabetes mellitus (KEGG) Viral carcinogenesis (KEGG) Viral myocarditis (KEGG) |
PDB | none |
OPM | none |
Complexes | none |
Interactions | none |
Domains | AA: 25-203, PDBID: 1A1M, Subunit A, Seq Identity:96%, Class I Histocompatibility antigen, domains alpha 1 and 2 AA: 209-290, PDBID: 1AGB, Subunit A, Seq Identity:100%, Immunoglobulin C1-set domain AA: 337-362, PDBID: 4EMZ, Subunit D, Seq Identity:86%, MHC_I C-terminus |
UniProt annotation for 1B59_HUMAN » HLA class I histocompatibility antigen, B-59 alpha chain |
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FUNCTION: Involved in the presentation of foreign antigens to the immune system. SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity). |
UniProt features for 1B59_HUMAN » HLA class I histocompatibility antigen, B-59 alpha chain |
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SIGNAL 1 24 CHAIN 25 362 HLA class I histocompatibility antigen, B-59 alpha chain. DOMAIN 209 295 Ig-like C1-type. REGION 25 114 Alpha-1. REGION 115 206 Alpha-2. REGION 207 298 Alpha-3. REGION 299 308 Connecting peptide. DISULFID 125 188 By similarity. DISULFID 227 283 By similarity. |
Amino Acid Sequence for 1B59_HUMAN » HLA class I histocompatibility antigen, B-59 alpha chain |
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MRVTAPRTLL LLLWGALALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI FKTNTQTYRE NLRIALRYYN QSEAGSHTWQ TMYGCDLGPD GRLLRGHNQL AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAARVAEQL RAYLEGTCVE WLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTIPIVG IVAGLAVLAV VVIGAVVATV MCRRKSSGGK GGSYSQAASS DSAQGSDVSL TA |