1B53_HUMAN » HLA class I histocompatibility antigen, B-53 alpha chain

1B53_HUMAN » HLA class I histocompatibility antigen, B-53 alpha chain
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
1B53_HUMAN » HLA class I histocompatibility antigen, B-53 alpha chain » Bw-53;MHC class I antigen B*53;
Hydrophobic Thickness 36.0 ± 3.6 Å
Tilt Angle 29 ± 0°
ΔGtransfer -27.9 kcal/mol
ΔGfold -23.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 305-331 (305-336)
Pathways

Allograft rejection (KEGG)

Antigen processing and presentation (KEGG)

Autoimmune thyroid disease (KEGG)

Cell adhesion molecules (KEGG)

Endocytosis (KEGG)

Epstein-Barr virus infection (KEGG)

Graft-versus-host disease (KEGG)

Herpes simplex infection (KEGG)

HTLV-I infection (KEGG)

Immune System (Reactome)

Natural killer cell mediated cytotoxicity (KEGG)

Phagosome (KEGG)

Type I diabetes mellitus (KEGG)

Viral carcinogenesis (KEGG)

Viral myocarditis (KEGG)

PDB 1a1m (A=25-300), 1a1o (A=25-300)
OPM none
Complexes none
Interactions none
Domains

AA: 25-203, PDBID: 1A1M, Subunit A, Seq Identity:100%, Class I Histocompatibility antigen, domains alpha 1 and 2

AA: 209-290, PDBID: 1A1M, Subunit A, Seq Identity:100%, Immunoglobulin C1-set domain

AA: 337-362, PDBID: 4EMZ, Subunit D, Seq Identity:86%, MHC_I C-terminus

UniProt annotation for 1B53_HUMAN » HLA class I histocompatibility antigen, B-53 alpha chain
FUNCTION: Involved in the presentation of foreign antigens to the immune system.

SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).

UniProt features for 1B53_HUMAN » HLA class I histocompatibility antigen, B-53 alpha chain
SIGNAL 1 24
CHAIN 25 362 HLA class I histocompatibility antigen, B-53 alpha chain.
DOMAIN 209 295 Ig-like C1-type.
REGION 25 114 Alpha-1.
REGION 115 206 Alpha-2.
REGION 207 298 Alpha-3.
REGION 299 308 Connecting peptide.
DISULFID 125 188
DISULFID 227 283
Amino Acid Sequence for 1B53_HUMAN » HLA class I histocompatibility antigen, B-53 alpha chain
MRVTAPRTVL LLLWGAVALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG YVDDTQFVRF DSDAASPRTE PRAPWIEQEG PEYWDRNTQI FKTNTQTYRE NLRIALRYYN QSEAGSHIIQ RMYGCDLGPD GRLLRGHDQS AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAARVAEQL RAYLEGLCVE WLRRYLENGK ETLQRADPPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTIPIVG IVAGLAVLAV VVIGAVVATV MCRRKSSGGK GGSYSQAASS DSAQGSDVSL TA