1B42_HUMAN » HLA class I histocompatibility antigen, B-42 alpha chain

1B42_HUMAN » HLA class I histocompatibility antigen, B-42 alpha chain
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
1B42_HUMAN » HLA class I histocompatibility antigen, B-42 alpha chain » MHC class I antigen B*42;
Hydrophobic Thickness 38.8 ± 2.4 Å
Tilt Angle 0 ± 1°
ΔGtransfer -49.4 kcal/mol
ΔGfold -23.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 305-331 (305-336)
Pathways

Allograft rejection (KEGG)

Antigen processing and presentation (KEGG)

Autoimmune thyroid disease (KEGG)

Cell adhesion molecules (KEGG)

Endocytosis (KEGG)

Epstein-Barr virus infection (KEGG)

Graft-versus-host disease (KEGG)

Herpes simplex infection (KEGG)

HTLV-I infection (KEGG)

Immune System (Reactome)

Natural killer cell mediated cytotoxicity (KEGG)

Phagosome (KEGG)

Type I diabetes mellitus (KEGG)

Viral carcinogenesis (KEGG)

Viral myocarditis (KEGG)

PDB none
OPM none
Complexes none
Interactions

CLIC1, Complex: 1B42:CLIC1, PubMed

CYB5B, Complex: 1B42:CYB5B, PubMed

LRC59, Complex: 1B42:LRC59, PubMed

OST48, Complex: 1B42:OST48, PubMed

PGRC1, Complex: 1B42:PGRC1, PubMed

RPN1, Complex: 1B42:RPN1, PubMed

SC11A, Complex: 1B42:SC11A, PubMed

SSRA, Complex: 1B42:SSRA, PubMed

TFR1, Complex: 1B42:TFR1, PubMed

VAPA, Complex: 1B42:VAPA, PubMed

Domains

AA: 25-203, PDBID: 4U1J, Subunit A, Seq Identity:100%, Class I Histocompatibility antigen, domains alpha 1 and 2

AA: 209-290, PDBID: 1AGB, Subunit A, Seq Identity:100%, Immunoglobulin C1-set domain

AA: 337-362, PDBID: 4EMZ, Subunit D, Seq Identity:82%, MHC_I C-terminus

UniProt annotation for 1B42_HUMAN » HLA class I histocompatibility antigen, B-42 alpha chain
FUNCTION: Involved in the presentation of foreign antigens to the immune system.

SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).

UniProt features for 1B42_HUMAN » HLA class I histocompatibility antigen, B-42 alpha chain
SIGNAL 1 24
CHAIN 25 362 HLA class I histocompatibility antigen, B-42 alpha chain.
DOMAIN 209 295 Ig-like C1-type.
REGION 25 114 Alpha-1.
REGION 115 206 Alpha-2.
REGION 207 298 Alpha-3.
REGION 299 309 Connecting peptide.
DISULFID 125 188 By similarity.
DISULFID 227 283 By similarity.
Amino Acid Sequence for 1B42_HUMAN » HLA class I histocompatibility antigen, B-42 alpha chain
MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKAQAQTDRE SLRNLRGYYN QSEAGSHTLQ SMYGCDVGPD GRLLRGHNQY AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAARVAEQD RAYLEGTCVE WLRRYLENGK DTLERADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS DSAQGSDVSL TA