1B27_HUMAN » HLA class I histocompatibility antigen, B-27 alpha chain

1B27_HUMAN » HLA class I histocompatibility antigen, B-27 alpha chain
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
1B27_HUMAN » HLA class I histocompatibility antigen, B-27 alpha chain » MHC class I antigen B*27;
Hydrophobic Thickness 38.8 ± 2.4 Å
Tilt Angle 0 ± 1°
ΔGtransfer -49.4 kcal/mol
ΔGfold -23.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 305-331 (305-336)
Pathways

Allograft rejection (KEGG)

Antigen processing and presentation (KEGG)

Autoimmune thyroid disease (KEGG)

Cell adhesion molecules (KEGG)

Endocytosis (KEGG)

Epstein-Barr virus infection (KEGG)

Graft-versus-host disease (KEGG)

Herpes simplex infection (KEGG)

HTLV-I infection (KEGG)

Immune System (Reactome)

Natural killer cell mediated cytotoxicity (KEGG)

Phagosome (KEGG)

Type I diabetes mellitus (KEGG)

Viral carcinogenesis (KEGG)

Viral myocarditis (KEGG)

PDB 1hsa (A/D=25-300), 2bst (A=25-300), 4g9f (A=25-300), 4g9d (A=25-300), 4g8i (A=25-300), 4g8g (A=25-300), 3lv3 (A=25-300), 3hcv (A=25-300), 3dtx (A=25-300), 3d18 (A=25-300), 3czf (A=25-300), 3bp7 (A=25-300), 3bp4 (A=25-300), 3b6s (A=25-300), 3b3i (A=25-300), 2bss (A=25-300), 2bsr (A=25-300), 2a83 (A=25-300), 1w0w (A=25-300), 1w0v (A=25-300), 1uxw (A=25-300), 1uxs (A=25-300), 1ogt (A=25-300), 1of2 (A=25-300), 1k5n (A=25-300), 1jge (A=25-300), 1jgd (A=25-300)
OPM none
Complexes none
Interactions none
Domains

AA: 25-203, PDBID: 1HSA, Subunit A, Seq Identity:100%, Class I Histocompatibility antigen, domains alpha 1 and 2

AA: 209-290, PDBID: 1AGB, Subunit A, Seq Identity:100%, Immunoglobulin C1-set domain

AA: 337-362, PDBID: 4EMZ, Subunit D, Seq Identity:82%, MHC_I C-terminus

UniProt annotation for 1B27_HUMAN » HLA class I histocompatibility antigen, B-27 alpha chain
FUNCTION: Involved in the presentation of foreign antigens to the immune system.

SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).

DISEASE: Spondyloarthropathy 1 (SPDA1) OMIM: A chronic rheumatic disease with multifactorial inheritance. It includes a spectrum of related disorders comprising ankylosing spondylitis, a subset of psoriatic arthritis, reactive arthritis (e.g. Reiter syndrome), arthritis associated with inflammatory bowel disease and undifferentiated spondyloarthropathy. These disorders may occur simultaneously or sequentially in the same patient, probably representing various phenotypic expressions of the same disease. Ankylosing spondylitis is the form of rheumatoid arthritis affecting the spine and is considered the prototype of seronegative spondyloarthropathies. It produces pain and stiffness as a result of inflammation of the sacroiliac, intervertebral, and costovertebral joints. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. A restricted number of HLA-B27 subtypes can be associated with ankylosing spondylitis and other B27-related diseases, and an elevated frequency of the B*2702 allele in ankylosing spondylitis patients is identified. The allele B*2707 seems to have a protective role some populations because it was found only in the healthy controls.

UniProt features for 1B27_HUMAN » HLA class I histocompatibility antigen, B-27 alpha chain
SIGNAL 1 24
CHAIN 25 362 HLA class I histocompatibility antigen, B-27 alpha chain.
DOMAIN 209 295 Ig-like C1-type.
REGION 25 114 Alpha-1.
REGION 115 206 Alpha-2.
REGION 207 298 Alpha-3.
REGION 299 308 Connecting peptide.
DISULFID 125 188
DISULFID 227 283
Amino Acid Sequence for 1B27_HUMAN » HLA class I histocompatibility antigen, B-27 alpha chain
MRVTAPRTLL LLLWGAVALT ETWAGSHSMR YFHTSVSRPG RGEPRFITVG YVDDTLFVRF DSDAASPREE PRAPWIEQEG PEYWDRETQI CKAKAQTDRE DLRTLLRYYN QSEAGSHTLQ NMYGCDVGPD GRLLRGYHQD AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAARVAEQL RAYLEGECVE WLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS DSAQGSDVSL TA