1B15_HUMAN » HLA class I histocompatibility antigen, B-15 alpha chain

1B15_HUMAN » HLA class I histocompatibility antigen, B-15 alpha chain
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
1B15_HUMAN » HLA class I histocompatibility antigen, B-15 alpha chain » MHC class I antigen B*15;
Hydrophobic Thickness 36.0 ± 3.6 Å
Tilt Angle 29 ± 0°
ΔGtransfer -27.9 kcal/mol
ΔGfold -23.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 305-331 (305-336)
Pathways

Allograft rejection (KEGG)

Antigen processing and presentation (KEGG)

Autoimmune thyroid disease (KEGG)

Cell adhesion molecules (KEGG)

Endocytosis (KEGG)

Epstein-Barr virus infection (KEGG)

Graft-versus-host disease (KEGG)

Herpes simplex infection (KEGG)

HTLV-I infection (KEGG)

Immune System (Reactome)

Natural killer cell mediated cytotoxicity (KEGG)

Phagosome (KEGG)

Type I diabetes mellitus (KEGG)

Viral carcinogenesis (KEGG)

Viral myocarditis (KEGG)

PDB 1xr8 (A=25-300), 1xr9 (A=25-300), 3c9n (A=25-300)
OPM none
Complexes none
Interactions

1A66, Complex: 1A66:1B15, PubMed

Domains

AA: 25-203, PDBID: 1XR8, Subunit A, Seq Identity:100%, Class I Histocompatibility antigen, domains alpha 1 and 2

AA: 209-290, PDBID: 1AGB, Subunit A, Seq Identity:100%, Immunoglobulin C1-set domain

AA: 337-362, PDBID: 4EMZ, Subunit D, Seq Identity:86%, MHC_I C-terminus

UniProt annotation for 1B15_HUMAN » HLA class I histocompatibility antigen, B-15 alpha chain
FUNCTION: Involved in the presentation of foreign antigens to the immune system.

SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).

DISEASE: Stevens-Johnson syndrome (SJS) OMIM: A rare blistering mucocutaneous disease that share clinical and histopathologic features with toxic epidermal necrolysis. Both disorders are characterized by high fever, malaise, and a rapidly developing blistering exanthema of macules and target-like lesions accompanied by mucosal involvement. Stevens-Johnson syndrome is a milder disease characterized by destruction and detachment of the skin epithelium and mucous membranes involving less than 10% of the body surface area. Ocular symptoms include ulcerative conjunctivitis, keratitis, iritis, uveitis and sometimes blindness. It can be caused by a severe adverse reaction to particular types of medication, although Mycoplasma infections may induce some cases. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Increased susceptibility to Stevens-Johnson syndrome is conferred by allele B*15:02.

UniProt features for 1B15_HUMAN » HLA class I histocompatibility antigen, B-15 alpha chain
SIGNAL 1 24
CHAIN 25 362 HLA class I histocompatibility antigen, B-15 alpha chain.
DOMAIN 209 295 Ig-like C1-type.
REGION 25 114 Alpha-1.
REGION 115 206 Alpha-2.
REGION 207 298 Alpha-3.
REGION 299 309 Connecting peptide.
DISULFID 125 188
DISULFID 227 283
Amino Acid Sequence for 1B15_HUMAN » HLA class I histocompatibility antigen, B-15 alpha chain
MRVTAPRTVL LLLSGALALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG YVDDTQFVRF DSDAASPRMA PRAPWIEQEG PEYWDRETQI SKTNTQTYRE SLRNLRGYYN QSEAGSHTLQ RMYGCDVGPD GRLLRGHDQS AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAAREAEQW RAYLEGLCVE WLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTIPIVG IVAGLAVLAV VVIGAVVATV MCRRKSSGGK GGSYSQAASS DSAQGSDVSL TA