1B07_HUMAN » HLA class I histocompatibility antigen, B-7 alpha chain

1B07_HUMAN » HLA class I histocompatibility antigen, B-7 alpha chain
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
1B07_HUMAN » HLA class I histocompatibility antigen, B-7 alpha chain » MHC class I antigen B*7;
Hydrophobic Thickness 38.8 ± 2.4 Å
Tilt Angle 0 ± 1°
ΔGtransfer -49.4 kcal/mol
ΔGfold -23.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 305-331 (305-336)
Pathways

Allograft rejection (KEGG)

Antigen processing and presentation (KEGG)

Autoimmune thyroid disease (KEGG)

Cell adhesion molecules (KEGG)

Endocytosis (KEGG)

Epstein-Barr virus infection (KEGG)

Graft-versus-host disease (KEGG)

Herpes simplex infection (KEGG)

HTLV-I infection (KEGG)

Immune System (Reactome)

Natural killer cell mediated cytotoxicity (KEGG)

Phagosome (KEGG)

Type I diabetes mellitus (KEGG)

Viral carcinogenesis (KEGG)

Viral myocarditis (KEGG)

PDB 3vcl (A=25-299)
OPM none
Complexes none
Interactions

1C03, Complex: 1B07:1C03.1C07, PubMed

1C04, Complex: 1B07:1C04, PubMed

ALK, Complex: ALK:1B07, PubMed

CD8A, Complex: 1B07:CD8A, PubMed

CLIC1, Complex: CLIC1:1B07, PubMed

CSF1, Complex: 1B07:CSF1, PubMed

EDEM1, Complex: 1B07:EDEM1

KI3L1, Complex: 1B07:KI3L1, PubMed

KI3S1, Complex: KI3S1:1B07, PubMed

KLRD1, Complex: 1B07:KLRD1, PubMed

LIRB1, Complex: LIRB1:1B07, PubMed

LIRB2, Complex: 1B07:LIRB2, PubMed

LRC59, Complex: 1B07:LRC59, PubMed

OST48, Complex: 1B07:OST48, PubMed

PGRC1, Complex: PGRC1:1B07, PubMed

RPN1, Complex: 1B07:RPN1, PubMed

SC11A, Complex: 1B07:SC11A, PubMed

SSRA, Complex: SSRA:1B07, PubMed

TFR1, Complex: TFR1:1B07, PubMed

TMED2, Complex: 1B07:TMED2, PubMed

UD11, Complex: UD11:1B07, PubMed

Domains

AA: 25-203, PDBID: 3VCL, Subunit A, Seq Identity:100%, Class I Histocompatibility antigen, domains alpha 1 and 2

AA: 209-290, PDBID: 1AGB, Subunit A, Seq Identity:100%, Immunoglobulin C1-set domain

AA: 337-362, PDBID: 4EMZ, Subunit D, Seq Identity:82%, MHC_I C-terminus

UniProt annotation for 1B07_HUMAN » HLA class I histocompatibility antigen, B-7 alpha chain
FUNCTION: Involved in the presentation of foreign antigens to the immune system.

SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity). Interacts with HTLV-1 accessory protein p12I.

UniProt features for 1B07_HUMAN » HLA class I histocompatibility antigen, B-7 alpha chain
SIGNAL 1 24
CHAIN 25 362 HLA class I histocompatibility antigen, B-7 alpha chain.
DOMAIN 209 295 Ig-like C1-type.
REGION 25 114 Alpha-1.
REGION 115 206 Alpha-2.
REGION 207 298 Alpha-3.
REGION 299 309 Connecting peptide.
DISULFID 125 188
DISULFID 227 283
Amino Acid Sequence for 1B07_HUMAN » HLA class I histocompatibility antigen, B-7 alpha chain
MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKAQAQTDRE SLRNLRGYYN QSEAGSHTLQ SMYGCDVGPD GRLLRGHDQY AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAAREAEQR RAYLEGECVE WLRRYLENGK DKLERADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS DSAQGSDVSL TA