1A11_HUMAN » HLA class I histocompatibility antigen, A-11 alpha chain

1A11_HUMAN » HLA class I histocompatibility antigen, A-11 alpha chain
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
1A11_HUMAN » HLA class I histocompatibility antigen, A-11 alpha chain » MHC class I antigen A*11;
Hydrophobic Thickness 37.6 ± 1.6 Å
Tilt Angle 0 ± 0°
ΔGtransfer -42.6 kcal/mol
ΔGfold -20.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 305-333 (305-336)
Pathways

Allograft rejection (KEGG)

Antigen processing and presentation (KEGG)

Autoimmune thyroid disease (KEGG)

Cell adhesion molecules (KEGG)

Endocytosis (KEGG)

Epstein-Barr virus infection (KEGG)

Graft-versus-host disease (KEGG)

Herpes simplex infection (KEGG)

HTLV-I infection (KEGG)

Natural killer cell mediated cytotoxicity (KEGG)

Phagosome (KEGG)

Type I diabetes mellitus (KEGG)

Viral carcinogenesis (KEGG)

Viral myocarditis (KEGG)

PDB 4beo (25-299), 4uq2 (A/C=25-299), 4n8v (A/D=25-298), 1q94 (A/D=25-299), 1qvo (A/D=25-299), 4mj5 (A=25-298), 4mj6 (A=25-298), 1x7q (A=25-299), 2hn7 (A=25-299)
OPM none
Complexes

KI2S2:A14:1A11:B2MG_HUMAN

Interactions

KI2S2, Complex: KI2S2:A14:1A11:B2MG, PDBID: 4N8V

Domains

AA: 25-203, PDBID: 1Q94, Subunit D, Seq Identity:100%, Class I Histocompatibility antigen, domains alpha 1 and 2

AA: 208-290, PDBID: 1Q94, Subunit D, Seq Identity:100%, Immunoglobulin C1-set domain

AA: 337-364, PDBID: 4EMZ, Subunit D, Seq Identity:96%, MHC_I C-terminus

UniProt annotation for 1A11_HUMAN » HLA class I histocompatibility antigen, A-11 alpha chain
FUNCTION: Involved in the presentation of foreign antigens to the immune system.

SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2- microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).

UniProt features for 1A11_HUMAN » HLA class I histocompatibility antigen, A-11 alpha chain
SIGNAL 1 24
CHAIN 25 365 HLA class I histocompatibility antigen, A-11 alpha chain.
DOMAIN 209 295 Ig-like C1-type.
REGION 25 114 Alpha-1.
REGION 115 206 Alpha-2.
REGION 207 298 Alpha-3.
REGION 299 308 Connecting peptide.
DISULFID 125 188
DISULFID 227 283
Amino Acid Sequence for 1A11_HUMAN » HLA class I histocompatibility antigen, A-11 alpha chain
MAVMAPRTLL LLLSGALALT QTWAGSHSMR YFYTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDQETRN VKAQSQTDRV DLGTLRGYYN QSEDGSHTIQ IMYGCDVGPD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITKRK WEAAHAAEQQ RAYLEGRCVE WLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEL SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS DSAQGSDVSL TACKV