1A02_HUMAN » HLA class I histocompatibility antigen, A-2 alpha chain

1A02_HUMAN » HLA class I histocompatibility antigen, A-2 alpha chain
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
1A02_HUMAN » HLA class I histocompatibility antigen, A-2 alpha chain » MHC class I antigen A*2;
Hydrophobic Thickness 34.4 ± 5.0 Å
Tilt Angle 32 ± 2°
ΔGtransfer -22.2 kcal/mol
ΔGfold -20.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 305-333 (305-336)
Pathways

Allograft rejection (KEGG)

Antigen processing and presentation (KEGG)

Autoimmune thyroid disease (KEGG)

Cell adhesion molecules (KEGG)

Endocytosis (KEGG)

Epstein-Barr virus infection (KEGG)

Graft-versus-host disease (KEGG)

Herpes simplex infection (KEGG)

HTLV-I infection (KEGG)

Immune System (Reactome)

Natural killer cell mediated cytotoxicity (KEGG)

Phagosome (KEGG)

Type I diabetes mellitus (KEGG)

Viral carcinogenesis (KEGG)

Viral myocarditis (KEGG)

PDB 4euq (25-299), 4l3c (A/C...=25-300), 4l29 (A/C...=25-300), 4uq3 (A/C=25-299), 3mgt (A/D/G/J=25-299), 3mgo (A/D/G/J=25-299), 3hae (A/D/J/P=25-300), 2guo (A/D=25-299), 3rew (A/D=25-299), 3qfd (A/D=25-299), 2x4n (A/D=25-299), 1tvh (A/D=25-299), 2x4o (A/D=25-299), 3pwn (A/D=25-299), 2gtz (A/D=25-299), 2gtw (A/D=25-299), 2av1 (A/D=25-299), 2av7 (A/D=25-299), 3v5k (A/D=25-299), 3v5h (A/D=25-299), 2clr (A/D=25-299), 3v5d (A/D=25-299), 2git (A/D=25-299), 2gt9 (A/D=25-299), 2x4p (A/D=25-299), 2x4q (A/D=25-299), 3o3b (A/D=25-299), 3o3a (A/D=25-299), 3giv (A/D=25-299), 3myj (A/D=25-299), 3h7b (A/D=25-299), 3h9h (A/D=25-299), 3kla (A/D=25-299), 3hpj (A/D=25-299), 3o3d (A/D=25-299), 3o3e (A/D=25-299), 2x4r (A/D=25-299), 2x4s (A/D=25-299), 2x4t (A/D=25-299), 2x4u (A/D=25-299), 2x70 (A/D=25-299), 3ixa (A/D=25-299), 3pwl (A/D=25-299), 3pwj (A/D=25-299), 3i6g (A/D=25-299), 4k7f (A/D=25-299), 4wj5 (A/D=25-299), 1i7u (A/D=25-299), 1i7t (A/D=25-299), 1i7r (A/D=25-299), 1i1y (A/D=25-299), 1i1f (A/D=25-299), 1hhk (A/D=25-299), 1hhj (A/D=25-299), 1hhi (A/D=25-299), 1hhg (A/D=25-299), 1eez (A/D=25-299), 1eey (A/D=25-299), 1duz (A/D=25-299), 1b0g (A/D=25-299), 1qr1 (A/D=25-299), 4jfo (A/D=25-299), 1duy (A/D=25-299), 4e5x (A/D=25-299), 1tvb (A/D=25-299), 4eup (A/D=25-299), 4jfp (A/D=25-300), 4gkn (A/D=25-300), 3gjf (A/D=25-300), 2c7u (A/D=25-300), 4jfq (A/D=25-300), 4gks (A/D=25-300), 2vll (A/D=25-300), 2v2x (A/D=25-300), 2v2w (A/D=25-300), 1im3 (A/E/I/M=25-299), 3i6k (A/E=25-299), 2f54 (A/F=25-298), 3utt (A/F=25-299), 3uts (A/F=25-300), 2vlr (A/F=25-300), 2uwe (A/H=25-299), 2j8u (A/H=25-299), 2jcc (A/H=25-299), 1lp9 (A/H=25-299), 1hla (A=25-294), 3hla (A=25-294), 4no2 (A=25-298), 3gso (A=25-298), 3gsq (A=25-298), 3gsr (A=25-298), 4nny (A=25-298), 3gsx (A=25-298), 3gsw (A=25-298), 4no3 (A=25-298), 1s9x (A=25-298), 1qrn (A=25-298), 1s9w (A=25-298), 3bgm (A=25-298), 3bhb (A=25-298), 3d25 (A=25-298), 1qse (A=25-298), 4nnx (A=25-298), 3bh8 (A=25-298), 1s9y (A=25-298), 1qsf (A=25-298), 4no5 (A=25-299), 3qfj (A=25-299), 3to2 (A=25-299), 4ftv (A=25-299), 4l3e (A=25-299), 3qdg (A=25-299), 3qeq (A=25-299), 3qdm (A=25-299), 3pwp (A=25-299), 3qdj (A=25-299), 1t21 (A=25-299), 3fqr (A=25-299), 3fqt (A=25-299), 3fqu (A=25-299), 3fqw (A=25-299), 3fqx (A=25-299), 3ft2 (A=25-299), 3ft3 (A=25-299), 3ft4 (A=25-299), 3fqn (A=25-299), 3d3v (A=25-299), 1t20 (A=25-299), 2f53 (A=25-299), 2gj6 (A=25-299), 1t1z (A=25-299), 1t1y (A=25-299), 1t22 (A=25-299), 3bh9 (A=25-299), 3d39 (A=25-299), 1t1x (A=25-299), 1t1w (A=25-299), 1s8d (A=25-299), 3h9s (A=25-299), 3gsv (A=25-299), 3gsu (A=25-299), 1ao7 (A=25-299), 1bd2 (A=25-299), 1b0r (A=25-299), 1jht (A=25-299), 1hhh (A=25-299), 1qew (A=25-299), 1i4f (A=25-299), 1jf1 (A=25-299), 3mrg (A=25-300), 1p7q (A=25-300), 1oga (A=25-300), 4no0 (A=25-300), 4jff (A=25-300), 1akj (A=25-300), 4i4w (A=25-300), 4jfd (A=25-300), 4u6x (A=25-300), 4qok (A=25-300), 4mnq (A=25-300), 4u6y (A=25-300), 4jfe (A=25-300), 3mr9 (A=25-300), 3mrn (A=25-300), 3mrm (A=25-300), 3mrl (A=25-300), 3mrk (A=25-300), 3mrj (A=25-300), 3mri (A=25-300), 3mrh (A=25-300), 3mrf (A=25-300), 3mre (A=25-300), 3mrd (A=25-300), 3mrc (A=25-300), 3mrb (A=25-300), 3mro (A=25-300), 3mrp (A=25-300), 3mrq (A=25-300), 2bnq (A=25-300), 2bnr (A=25-300), 2p5e (A=25-300), 3utq (A=25-300), 2p5w (A=25-300), 2pye (A=25-300), 2vlj (A=25-300), 2vlk (A=25-300), 3o4l (A=25-300), 3mrr (A=25-300), 4ov5 (C/F...=128-141), 1aqd (C/F/I/L=127-141), 4en2 (D/E=338-365), 4emz (D/E=338-365), 3gsn (H=25-298)
OPM none
Complexes

CD8A:1A02:B2MG_HUMAN

CTG1B:TCA:TRBC1:1A02:B2MG_HUMAN

M1:TCA:TRBC1:1A02:B2MG_HUMAN

ICP27:Q8WLS4:TCA:TRBC1:1A02:B2MG_HUMAN

CTG1B:TRBC2:TCA:1A02:B2MG_HUMAN

EMC7:TCA:1A02:B2MG_HUMAN

TVB5:EMC7:TCA:1A02:B2MG_HUMAN

TCA:TRBC1:MAR1:1A02:B2MG_HUMAN

A0A585:H2RG00:K7N5N2:TERT:TRBC1:1A02:B2MG_HUMAN

TAX:TRBC1:1A02:B2MG_HUMAN

TCA:TRBC1:1A02:B2MG_HUMAN

LIRB1:LSP1:1A02:B2MG_HUMAN

POL:LIRB1:1A02:B2MG_HUMAN

DRA:2B11:1A02_HUMAN

ERBB2:1A02:B2MG_HUMAN

EMC7:1A02:B2MG_HUMAN

MAR1:1A02:B2MG_HUMAN

PMEL:1A02:B2MG_HUMAN

Interactions

2B11, Complex: 1A02:2B11:2DRA, PDBID: 1AQD

CD8A, Complex: 1A02:B2MG:CD8A, PDBID: 1akj

EGFR, Complex: 1A02:EGFR, PubMed

EMC7, Complex: EMC7:1A02:B2MG, PDBID: 1B0G

ERBB2, Complex: 1A02:B2MG:ERBB2, PDBID: 1qr1

LIRB1, Complex: 1A02:B2MG:LIRB1, PDBID: 1p7q

MAR1, Complex: 1A02:B2MG:MAR1, PDBID: 2gt9

NEP, Complex: 1A02:NEP

PMEL, Complex: PMEL:1A02:B2MG, PDBID: 1TVB

TCA, Complex: 1A02:B2MG:TCA, PDBID: 1oga

TRBC1, Complex: TAX:TRBC1:1A02:B2MG, PDBID: 1AO7

Domains

AA: 25-203, PDBID: 1AKJ, Subunit A, Seq Identity:100%, Class I Histocompatibility antigen, domains alpha 1 and 2

AA: 209-290, PDBID: 1AKJ, Subunit A, Seq Identity:100%, Immunoglobulin C1-set domain

AA: 337-364, PDBID: 4EMZ, Subunit D, Seq Identity:100%, MHC_I C-terminus

UniProt annotation for 1A02_HUMAN » HLA class I histocompatibility antigen, A-2 alpha chain
FUNCTION: Involved in the presentation of foreign antigens to the immune system.

SUBUNIT: Dimer of alpha chain and a beta chain (beta-2- microglobulin). Interacts with human herpesvirus 8 MIR1 protein. Interacts with HTLV-1 accessory protein p12I.

UniProt features for 1A02_HUMAN » HLA class I histocompatibility antigen, A-2 alpha chain
SIGNAL 1 24
CHAIN 25 365 HLA class I histocompatibility antigen, A-2 alpha chain.
DOMAIN 209 295 Ig-like C1-type.
REGION 25 114 Alpha-1.
REGION 115 206 Alpha-2.
REGION 207 298 Alpha-3.
REGION 299 308 Connecting peptide.
DISULFID 125 188
DISULFID 227 283
Amino Acid Sequence for 1A02_HUMAN » HLA class I histocompatibility antigen, A-2 alpha chain
MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDGETRK VKAHSQTHRV DLGTLRGYYN QSEAGSHTVQ RMYGCDVGSD WRFLRGYHQY AYDGKDYIAL KEDLRSWTAA DMAAQTTKHK WEAAHVAEQL RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP SSQPTIPIVG IIAGLVLFGA VITGAVVAAV MWRRKSSDRK GGSYSQAASS DSAQGSDVSL TACKV