1.11.03. Peptidase clan MA (CL0126) (53 proteins)

Family Protein Name Protein ID Species Localization Topology TM Segment (helix) Hydrophobic Thickness (Å) Tilt Angle (°) ΔGfold (kcal/mol) ΔGtransf (kcal/mol)
1.11.03.01. Glutamyl aminopeptidase AMPE_HUMAN Homo sapiens Plasma memb. In 14-40 (7-42) 30.0 ± 2.0 0 ± 2 -16.2 -34.8
1.11.03.01. Aminopeptidase N AMPN_HUMAN Homo sapiens Plasma memb. In 10-33 (6-39) 32.8 ± 1.6 1 ± 1 -18.0 -38.2
1.11.03.01. Aminopeptidase Q AMPQ_HUMAN Homo sapiens Vesicle memb. In 14-36 (6-37) 42.0 ± 4.2 0 ± 5 -25.9 -38.7
1.11.03.01. Endoplasmic reticulum aminopeptidase 1 ERAP1_HUMAN Homo sapiens ER memb. In 6-27 (5-28) 30.8 ± 2.8 16 ± 14 -11.9 -19.0
1.11.03.01. Leucyl-cystinyl aminopeptidase LCAP_HUMAN Homo sapiens Plasma memb. In 108-131 (106-131) 31.6 ± 1.4 2 ± 0 -18.6 -38.1
1.11.03.01. Thyrotropin-releasing hormone-degrading ectoenzyme TRHDE_HUMAN Homo sapiens Plasma memb. In 34-65 (34-65) 38.4 ± 3.0 4 ± 1 -24.6 -49.6
1.11.03.01. Uncharacterized protein Q557I4_DICDI Dictyostelium discoideum Membrane In 58-80 (55-83) 34.4 ± 3.4 8 ± 7 -18.9 -27.9
1.11.03.02. Angiotensin-converting enzyme 2 ACE2_HUMAN Homo sapiens Plasma memb. Out 738-765 (738-770) 37.6 ± 2.2 0 ± 1 -26.4 -59.1
1.11.03.02. Angiotensin-converting enzyme ACE_HUMAN Homo sapiens Plasma memb. Out 1256-1275 (1251-1277) 29.8 ± 3.0 8 ± 4 -18.2 -21.4
1.11.03.02. Collectrin TMM27_HUMAN Homo sapiens Plasma memb. Out 140-167 (139-171) 36.8 ± 4.6 23 ± 3 -29.5 -31.7
1.11.03.03. Matrix metalloproteinase-14 MMP14_HUMAN Homo sapiens Plasma memb. Out 537-562 (536-565) 34.0 ± 4.0 30 ± 0 -27.9 -32.7
1.11.03.03. Matrix metalloproteinase-15 MMP15_HUMAN Homo sapiens Plasma memb. Out 621-646 (618-651) 35.2 ± 2.6 20 ± 10 -22.7 -28.6
1.11.03.03. Matrix metalloproteinase-16 MMP16_HUMAN Homo sapiens Plasma memb. Out 559-588 (558-590) 39.2 ± 4.2 30 ± 15 -22.5 -30.3
1.11.03.03. Matrix metalloproteinase-23 MMP23_HUMAN Homo sapiens Plasma memb. In 19-40 (16-40) 32.2 ± 2.6 15 ± 8 -14.0 -19.9
1.11.03.03. Matrix metalloproteinase-24 MMP24_HUMAN Homo sapiens Plasma memb. Out 601-626 (599-628) 34.4 ± 3.0 19 ± 2 -15.9 -22.7
1.11.03.04. Meprin A subunit alpha MEP1A_HUMAN Homo sapiens Plasma memb. Out 718-740 (717-742) 32.4 ± 2.0 0 ± 2 -12.8 -41.3
1.11.03.04. Meprin A subunit beta MEP1B_HUMAN Homo sapiens Plasma memb. Out 655-677 (652-685) 33.2 ± 2.6 0 ± 0 -23.4 -48.8
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 10 ADA10_HUMAN Homo sapiens Plasma memb. Out 671-699 (670-702) 38.0 ± 6.4 30 ± 0 -23.3 -25.9
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 11 ADA11_HUMAN Homo sapiens Plasma memb. Out 732-758 (730-764) 34.4 ± 2.8 0 ± 4 -12.9 -41.5
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 12 ADA12_HUMAN Homo sapiens Plasma memb. Out 707-730 (705-732) 32.4 ± 2.2 1 ± 1 -19.5 -46.0
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 15 ADA15_HUMAN Homo sapiens Plasma memb. Out 692-717 (690-719) 34.4 ± 2.8 2 ± 1 -21.7 -42.5
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 17 ADA17_HUMAN Homo sapiens Plasma memb. Out 669-698 (669-698) 30.4 ± 2.2 1 ± 1 -10.7 -32.8
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 18 ADA18_HUMAN Homo sapiens Plasma memb. Out 687-709 (687-710) 27.2 ± 1.6 3 ± 2 -17.3 -42.8
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 19 ADA19_HUMAN Homo sapiens Plasma memb. Out 701-725 (701-726) 35.2 ± 1.4 17 ± 10 -20.4 -28.4
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 20 ADA20_HUMAN Homo sapiens Plasma memb. Out 691-715 (687-720) 32.0 ± 1.8 1 ± 0 -21.8 -36.0
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 21 ADA21_HUMAN Homo sapiens Plasma memb. Out 679-707 (675-711) 42.4 ± 4.8 2 ± 1 -16.0 -29.6
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 22 ADA22_HUMAN Homo sapiens Plasma memb. Out 732-760 (732-767) 36.0 ± 1.2 0 ± 2 -21.7 -51.4
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 23 ADA23_HUMAN Homo sapiens Plasma memb. Out 791-816 (788-822) 32.0 ± 1.8 40 ± 12 -14.1 -17.1
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 28 ADA28_HUMAN Homo sapiens Plasma memb. Out 661-689 (657-693) 37.6 ± 3.0 20 ± 1 -23.9 -30.8
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 29 ADA29_HUMAN Homo sapiens Plasma memb. Out 673-695 (668-701) 34.8 ± 2.2 4 ± 3 -23.0 -26.6
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 30 ADA30_HUMAN Homo sapiens Plasma memb. Out 687-711 (683-711) 36.8 ± 2.0 0 ± 1 -17.1 -55.4
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 32 ADA32_HUMAN Homo sapiens Plasma memb. Out 681-705 (680-705) 34.8 ± 2.0 10 ± 8 -19.6 -25.0
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 33 ADA33_HUMAN Homo sapiens Plasma memb. Out 699-725 (699-727) 34.4 ± 5.6 32 ± 2 -11.4 -21.4
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 2 ADAM2_HUMAN Homo sapiens Plasma memb. Out 687-711 (686-714) 31.6 ± 1.2 0 ± 0 -21.4 -44.8
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 7 ADAM7_HUMAN Homo sapiens Plasma memb. Out 665-692 (661-696) 40.0 ± 4.8 16 ± 13 -27.2 -34.8
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 8 ADAM8_HUMAN Homo sapiens Plasma memb. Out 653-681 (653-683) 35.6 ± 3.8 32 ± 0 -29.4 -33.7
1.11.03.05. Disintegrin and metalloproteinase domain-containing protein 9 ADAM9_HUMAN Homo sapiens Plasma memb. Out 693-719 (693-721) 34.4 ± 4.0 30 ± 23 -21.1 -31.5
1.11.03.06. Endothelin-converting enzyme 1 ECE1_HUMAN Homo sapiens Plasma memb. In 64-89 (64-95) 35.6 ± 1.4 1 ± 1 -21.2 -30.4
1.11.03.06. Endothelin-converting enzyme 2 ECE2_HUMAN Homo sapiens Golgi memb. In 176-201 (176-206) 35.2 ± 3.4 0 ± 0 -21.0 -36.2
1.11.03.06. Endothelin-converting enzyme-like 1 ECEL1_HUMAN Homo sapiens Plasma memb. In 60-85 (57-85) 30.4 ± 1.8 1 ± 1 -18.8 -35.8
1.11.03.06. Kell blood group glycoprotein KELL_HUMAN Homo sapiens Plasma memb. In 45-69 (41-70) 36.4 ± 3.0 16 ± 7 -18.6 -26.1
1.11.03.06. Membrane metallo-endopeptidase-like 1 MMEL1_HUMAN Homo sapiens Plasma memb. In 25-49 (25-51) 36.4 ± 2.6 8 ± 10 -20.6 -27.7
1.11.03.06. Neprilysin NEP_HUMAN Homo sapiens Plasma memb. In 26-51 (26-52) 35.2 ± 2.2 29 ± 6 -25.8 -28.6
1.11.03.06. Phosphate-regulating neutral endopeptidase PHEX_HUMAN Homo sapiens Plasma memb. In 18-40 (17-50) 33.6 ± 1.8 0 ± 1 -14.9 -44.7
1.11.03.07. Probable carboxypeptidase S-like 2 CBPS2_DICDI Dictyostelium discoideum Membrane In 24-52 (24-54) 28.8 ± 3.0 47 ± 0 -14.5 -23.7
1.11.03.07. Putative carboxypeptidase YOL153C CBPS2_YEAST Saccharomyces cerevisiae Membrane In 26-46 (23-49) 29.2 ± 3.7 1 ± 0 -12.7 -22.4
1.11.03.07. Carboxypeptidase S CBPS_YEAST Saccharomyces cerevisiae Vacuole memb. In 20-40 (14-41) 31.8 ± 2.9 1 ± 0 -14.5 -20.9
1.11.03.07. Uncharacterized protein YgeY YGEY_ECOLI Escherichia coli Gram-neg. inner Out 381-401 (378-402) 26.4 ± 2.4 7 ± 0 -7.4 -23.9
1.11.03.08. Uncharacterized peptidase YFR006W YFH6_YEAST Saccharomyces cerevisiae Membrane Out 5-25 (5-31) 32.8 ± 2.7 9 ± 8 -10.8 -20.3
1.11.03.09. MIFR-2 O75086_HUMAN Homo sapiens Plasma memb. In 19-40 (16-40) 32.2 ± 2.6 15 ± 8 -14.0 -19.9
1.11.03.10. GP63 Q6TU47_DICDI Dictyostelium discoideum Plasma memb. Out 660-682 (659-682) 33.4 ± 2.7 5 ± 3 -11.9 -21.7
1.11.03.10. Uncharacterized protein Q54LN5_DICDI Dictyostelium discoideum Plasma memb. Out 745-766 (744-771) 25.2 ± 1.0 0 ± 0 -12.5 -28.1
1.11.03.11. Uncharacterized protein Q54HN7_DICDI Dictyostelium discoideum Membrane Und 350-370 (348-372) 29.8 ± 2.8 5 ± 3 -7.9 -15.1