Superfamily » 1.05.03. EMP24/GP25L family - <a href="http://pfam.xfam.org/family?PF01105" class="external" target="_blank">PF01105 (Pfam)</a>

Type:1. Transmembrane bitopic proteins
Class:1.05. Membrane trafficking and biogenesis
Superfamily:1.05.03. EMP24/GP25L family - PF01105 (Pfam)
Family:
1. 1.05.03.01.
  TMP21-related IPR015720 (InterPro)
  Emp24/gp25L/p24 family protein
  
  Dictyostelium discoideum
  (Q769F6_DICDI)
  
  Dictyostelium discoideum
  (Q769F7_DICDI)
  
  Endoplasmic reticulum vesicle protein 25
  
  Saccharomyces cerevisiae
  (TMEDA_YEAST, ALG5, CP51, CUE1, CWH41, DPM1, EMP24, EMP47, ERG2, ERG5, ERP1, ERP2, ERP3, ERP4, ERP5, ERP6, GLRX2, GPI16, GPI8, GSF2, HLJ1, HOC1, IRE1, KTR3, MMM1, MNN11, MNN2, MSMO, NCB5R, OST1, OSTB, PMP2, SAC1, SCS2, SEC11, SEC22, SEC66, SED4, SED5, TLG2, TMEDA, UBX2, YE053)
  
  Endosomal protein P24B
  
  Saccharomyces cerevisiae
  (EMP24_YEAST, ALG1, ALG5, CWH41, ERG2, ERP1, ERP1, ERP2, ERP3, ERP3, ERP4, ERP5, ERP6, FIS1, GEM1, GSF2, HKR1, HOC1, IRE1, KRE6, MKAR, MNL2, MSMO, OST4, PHB2, PMP2, ROT1, SC61G, SCS2, SEC22, SED5, SNL1, SOP4, SRPB, TLG2, TMEDA)
  
  Protein ERP1
  
  Saccharomyces cerevisiae
  (ERP1_YEAST, ALG5, BET1, CALX, CP51, CWH41, EMP24, EMP24, EMP47, ERG2, ERG5, ERP2, ERP3, ERP4, ERP5, ERP6, GLRX2, GSF2, IRE1, MSMO, NCB5R, OST1, OSTB, PMP2, SAC1, SCS2, SEC22, SEC66, SED4, SED5, TLG2, TMEDA, YE053)
  
  Protein ERP2
  
  Saccharomyces cerevisiae
  (ERP2_YEAST, CALX, CP51, EMP24, EMP47, ERP1, ERP3, ERP4, ERP5, ERP6, MSMO, NCB5R, OSTB, PHB2, SAC1, SC61G, SEC22, SED5, TLG2, TMEDA)
  
  Protein ERP3
  
  Saccharomyces cerevisiae
  (ERP3_YEAST, EMP24, ERP1, ERP2, ERP4, ERP5, ERP6, FMP32, HPH1, HPH2, MPS3, MSMO, PLSC, SAC1, SED5, TMEDA, VPS64)
  
  Protein ERP4
  
  Saccharomyces cerevisiae
  (ERP4_YEAST, EMP24, EMP24, ERP1, ERP2, ERP3, ERP5, ERP6, FET3, IRC23, MSMO, OST1, OSTB, PMP2, SAC1, TLG2, TMEDA, TOM70, YE053)
  
  Protein ERP5
  
  Saccharomyces cerevisiae
  (ERP5_YEAST, ANP1, COX8, EMP24, ERP1, ERP2, ERP3, ERP4, ERP6, GSF2, HUR1, IRE1, MKAR, OST1, PMP2, PSD1, SAC1, TLG2, TMEDA)
  
  Protein ERP6
  
  Saccharomyces cerevisiae
  (ERP6_YEAST, EMP24, ERP1, ERP2, ERP3, ERP4, ERP5, OST1, PMP2, TMEDA)
  
  Transmembrane emp24 domain-containing protein 1
  
  Homo sapiens
  (TMED1_HUMAN, ILRL1, TMED9)
  
  Transmembrane emp24 domain-containing protein 10
  
  Homo sapiens
  (TMEDA_HUMAN, ESR1, NICA, PTN2, PYRD, RYK, SC22B, TGFA, TMED2, TMED7, TMED9, TMEDA, VAMP2)
  
  Transmembrane emp24 domain-containing protein 2
  
  Homo sapiens
  (TMED2_HUMAN, 1B07, ESR1, LMAN1, NICA, TMED4, TMED7, TMED9, TMEDA)
  
  Transmembrane emp24 domain-containing protein 3
  
  Homo sapiens
  (TMED3_HUMAN)
  
  Transmembrane emp24 domain-containing protein 4
  
  Homo sapiens
  (TMED4_HUMAN, IKIP, SRPRB, TMED2)
  
  Transmembrane emp24 domain-containing protein 5
  
  Homo sapiens
  (TMED5_HUMAN, LMAN1)
  
  Transmembrane emp24 domain-containing protein 6
  
  Homo sapiens
  (TMED6_HUMAN)
  
  Transmembrane emp24 domain-containing protein 7
  
  Homo sapiens
  (TMED7_HUMAN, IL1AP, IL1R1, TLR3, TLR4, TMED2, TMED9, TMEDA, TMPS3)
  
  Transmembrane emp24 domain-containing protein 9
  
  Homo sapiens
  (TMED9_HUMAN, MA2A1, PTN2, SC22B, STX5, TMED1, TMED2, TMED7, TMEDA)
  
  Transmembrane emp24 domain-containing protein A
  
  Dictyostelium discoideum
  (TMEDA_DICDI)
  
  Transmembrane emp24 domain-containing protein B
  
  Dictyostelium discoideum
  (TMEDB_DICDI)
  
  Transmembrane emp24 domain-containing protein p24beta2
  
  Arabidopsis thaliana
  (P24B2_ARATH, BETL2, P24D5, PAM74, WAK3)
  
  Transmembrane emp24 domain-containing protein p24beta3
  
  Arabidopsis thaliana
  (P24B3_ARATH, BETL2, MSBP1, PAM74, SSRA, UBC34, WAK3)
  
  Transmembrane emp24 domain-containing protein p24delta10
  
  Arabidopsis thaliana
  (P24DA_ARATH, BETL2, C71B4, CRK40, ERL1, PAM74, UBC34, WAK3)
  
  Transmembrane emp24 domain-containing protein p24delta11
  
  Arabidopsis thaliana
  (P24DB_ARATH)
  
  Transmembrane emp24 domain-containing protein p24delta3
  
  Arabidopsis thaliana
  (P24D3_ARATH, BETL2, PAM74, WAK3)
  
  Transmembrane emp24 domain-containing protein p24delta4
  
  Arabidopsis thaliana
  (P24D4_ARATH)
  
  Transmembrane emp24 domain-containing protein p24delta5
  
  Arabidopsis thaliana
  (P24D5_ARATH, P24B2)
  
  Transmembrane emp24 domain-containing protein p24delta6
  
  Arabidopsis thaliana
  (P24D6_ARATH)
  
  Transmembrane emp24 domain-containing protein p24delta7
  
  Arabidopsis thaliana
  (P24D7_ARATH)
  
  Transmembrane emp24 domain-containing protein p24delta8
  
  Arabidopsis thaliana
  (P24D8_ARATH)
  
  Transmembrane emp24 domain-containing protein p24delta9
  
  Arabidopsis thaliana
  (P24D9_ARATH)

1.05.03. EMP24/GP25L family - PF01105 (Pfam) (32 proteins)

Family	Protein Name	Protein ID	Species	Localization	Topology	TM Segment (helix)	Hydrophobic Thickness (Å)	Tilt Angle (°)	ΔG_fold (kcal/mol)	ΔG_transf (kcal/mol)
1.05.03.01.	Transmembrane emp24 domain-containing protein 1	TMED1_HUMAN	Homo sapiens	Plasma memb.	Out	195-219 (195-222)	27.6 ± 2.4	2 ± 1	-13.9	-31.4
1.05.03.01.	Transmembrane emp24 domain-containing protein 2	TMED2_HUMAN	Homo sapiens	Vesicle memb.	Out	169-191 (163-198)	32.0 ± 2.0	1 ± 2	-12.4	-35.9
1.05.03.01.	Transmembrane emp24 domain-containing protein 3	TMED3_HUMAN	Homo sapiens	ER memb.	Out	186-206 (186-209)	20.8 ± 0.6	4 ± 1	-8.6	-19.0
1.05.03.01.	Transmembrane emp24 domain-containing protein 4	TMED4_HUMAN	Homo sapiens	ER memb.	Out	196-217 (188-224)	34.4 ± 3.8	0 ± 0	-10.8	-34.9
1.05.03.01.	Transmembrane emp24 domain-containing protein 5	TMED5_HUMAN	Homo sapiens	ER memb.	Out	197-221 (197-227)	31.2 ± 3.2	37 ± 0	-13.1	-21.4
1.05.03.01.	Transmembrane emp24 domain-containing protein 6	TMED6_HUMAN	Homo sapiens	ER memb.	Out	203-223 (203-225)	26.0 ± 1.4	0 ± 0	-8.6	-30.0
1.05.03.01.	Transmembrane emp24 domain-containing protein 7	TMED7_HUMAN	Homo sapiens	ER memb.	Out	188-212 (188-215)	23.6 ± 3.4	1 ± 0	-7.5	-21.5
1.05.03.01.	Transmembrane emp24 domain-containing protein 9	TMED9_HUMAN	Homo sapiens	ER memb.	Out	203-225 (197-232)	32.0 ± 1.4	2 ± 0	-12.2	-38.2
1.05.03.01.	Transmembrane emp24 domain-containing protein 10	TMEDA_HUMAN	Homo sapiens	Golgi memb.	Out	186-208 (180-215)	34.0 ± 1.6	1 ± 1	-15.9	-43.9
1.05.03.01.	Transmembrane emp24 domain-containing protein p24beta2	P24B2_ARATH	Arabidopsis thaliana	Golgi memb.	Out	173-195 (167-202)	27.6 ± 3.6	0 ± 3	-9.6	-33.8
1.05.03.01.	Transmembrane emp24 domain-containing protein p24beta3	P24B3_ARATH	Arabidopsis thaliana	Golgi memb.	Out	177-200 (173-203)	31.6 ± 4.0	23 ± 15	-7.3	-15.2
1.05.03.01.	Transmembrane emp24 domain-containing protein p24delta3	P24D3_ARATH	Arabidopsis thaliana	ER memb.	Out	187-207 (183-214)	32.8 ± 1.4	0 ± 0	-10.6	-36.8
1.05.03.01.	Transmembrane emp24 domain-containing protein p24delta4	P24D4_ARATH	Arabidopsis thaliana	ER memb.	Out	182-202 (178-209)	34.0 ± 2.2	7 ± 0	-12.0	-37.6
1.05.03.01.	Transmembrane emp24 domain-containing protein p24delta5	P24D5_ARATH	Arabidopsis thaliana	ER memb.	Out	183-208 (178-213)	33.6 ± 2.4	0 ± 2	-11.5	-38.0
1.05.03.01.	Transmembrane emp24 domain-containing protein p24delta6	P24D6_ARATH	Arabidopsis thaliana	ER memb.	Out	187-208 (187-214)	27.6 ± 2.7	34 ± 0	-11.0	-16.2
1.05.03.01.	Transmembrane emp24 domain-containing protein p24delta7	P24D7_ARATH	Arabidopsis thaliana	ER memb.	Out	179-204 (174-209)	32.0 ± 2.0	0 ± 0	-14.8	-33.6
1.05.03.01.	Transmembrane emp24 domain-containing protein p24delta8	P24D8_ARATH	Arabidopsis thaliana	ER memb.	Out	179-205 (175-210)	30.8 ± 1.4	41 ± 0	-13.0	-16.9
1.05.03.01.	Transmembrane emp24 domain-containing protein p24delta9	P24D9_ARATH	Arabidopsis thaliana	ER memb.	Out	180-206 (176-211)	40.4 ± 1.4	0 ± 0	-15.9	-46.3
1.05.03.01.	Transmembrane emp24 domain-containing protein p24delta10	P24DA_ARATH	Arabidopsis thaliana	ER memb.	Out	181-206 (176-211)	35.6 ± 1.8	1 ± 0	-15.9	-46.8
1.05.03.01.	Transmembrane emp24 domain-containing protein p24delta11	P24DB_ARATH	Arabidopsis thaliana	ER memb.	Out	193-213 (189-222)	32.6 ± 2.8	0 ± 0	-13.5	-17.0
1.05.03.01.	Emp24/gp25L/p24 family protein	Q769F6_DICDI	Dictyostelium discoideum	Plasma memb.	Out	189-212 (183-218)	34.4 ± 2.2	9 ± 8	-14.1	-18.6
1.05.03.01.	Emp24/gp25L/p24 family protein	Q769F7_DICDI	Dictyostelium discoideum	Plasma memb.	Out	182-204 (176-211)	26.4 ± 4.2	2 ± 1	-13.2	-33.7
1.05.03.01.	Transmembrane emp24 domain-containing protein A	TMEDA_DICDI	Dictyostelium discoideum	Vesicle memb.	Out	173-195 (165-202)	27.2 ± 3.4	1 ± 1	-14.7	-36.5
1.05.03.01.	Transmembrane emp24 domain-containing protein B	TMEDB_DICDI	Dictyostelium discoideum	Vesicle memb.	Out	175-197 (169-198)	28.0 ± 3.8	3 ± 0	-9.0	-33.4
1.05.03.01.	Endoplasmic reticulum vesicle protein 25	TMEDA_YEAST	Saccharomyces cerevisiae	ER memb.	Out	178-198 (173-208)	31.2 ± 2.8	5 ± 7	-11.6	-17.5
1.05.03.01.	Protein ERP6	ERP6_YEAST	Saccharomyces cerevisiae	ER memb.	Out	185-206 (182-207)	30.0 ± 3.0	0 ± 3	-11.9	-40.9
1.05.03.01.	Protein ERP5	ERP5_YEAST	Saccharomyces cerevisiae	ER memb.	Out	181-202 (172-203)	27.2 ± 1.8	5 ± 2	-13.7	-30.2
1.05.03.01.	Endosomal protein P24B	EMP24_YEAST	Saccharomyces cerevisiae	Vesicle memb.	Out	173-193 (169-198)	29.2 ± 1.6	0 ± 1	-7.6	-30.4
1.05.03.01.	Protein ERP1	ERP1_YEAST	Saccharomyces cerevisiae	ER memb.	Out	187-207 (179-209)	25.2 ± 3.0	2 ± 0	-12.6	-29.9
1.05.03.01.	Protein ERP2	ERP2_YEAST	Saccharomyces cerevisiae	ER memb.	Out	181-209 (176-212)	28.8 ± 2.8	48 ± 0	-27.3	-28.5
1.05.03.01.	Protein ERP3	ERP3_YEAST	Saccharomyces cerevisiae	ER memb.	Out	187-216 (187-221)	29.6 ± 1.6	51 ± 0	-16.0	-20.9
1.05.03.01.	Protein ERP4	ERP4_YEAST	Saccharomyces cerevisiae	ER memb.	Out	173-198 (168-204)	30.8 ± 6.2	37 ± 0	-21.0	-23.0