1.03.01. Immunoglobulin superfamily (90 proteins)

Family Protein Name Protein ID Species Localization Topology TM Segment (helix) Hydrophobic Thickness (Å) Tilt Angle (°) ΔGfold (kcal/mol) ΔGtransf (kcal/mol)
1.03.01.01. B-cell receptor CD22 CD22_HUMAN Homo sapiens Plasma memb. Out 687-708 (681-710) 33.2 ± 2.4 2 ± 2 -14.0 -16.6
1.03.01.01. Myeloid cell surface antigen CD33 CD33_HUMAN Homo sapiens Plasma memb. Out 263-285 (261-290) 27.6 ± 1.8 0 ± 0 -16.8 -38.9
1.03.01.01. SIGLEC family-like protein 1 SIGL1_HUMAN Homo sapiens Plasma memb. Out 115-141 (115-147) 34.0 ± 2.6 34 ± 2 -18.7 -24.0
1.03.01.01. Myelin-associated glycoprotein MAG_HUMAN Homo sapiens Plasma memb. Out 514-535 (514-539) 26.0 ± 1.6 0 ± 0 -17.7 -34.1
1.03.01.01. Sialic acid-binding Ig-like lectin 10 SIG10_HUMAN Homo sapiens Plasma memb. Out 548-574 (546-574) 31.2 ± 3.0 0 ± 0 -19.1 -46.3
1.03.01.01. Sialic acid-binding Ig-like lectin 11 SIG11_HUMAN Homo sapiens Plasma memb. Out 549-574 (549-586) 34.4 ± 3.8 29 ± 9 -13.0 -17.8
1.03.01.01. Sialic acid-binding Ig-like lectin 12 SIG12_HUMAN Homo sapiens Plasma memb. Out 482-504 (476-510) 37.6 ± 2.6 0 ± 0 -15.3 -39.9
1.03.01.01. Sialic acid-binding Ig-like lectin 14 SIG14_HUMAN Homo sapiens Plasma memb. Out 355-380 (355-384) 35.2 ± 1.0 26 ± 0 -9.9 -22.4
1.03.01.01. Sialic acid-binding Ig-like lectin 15 SIG15_HUMAN Homo sapiens Plasma memb. Out 262-284 (258-289) 34.6 ± 1.2 11 ± 10 -15.7 -20.5
1.03.01.01. Sialic acid-binding Ig-like lectin 16 SIG16_HUMAN Homo sapiens Plasma memb. Out 431-456 (431-467) 34.8 ± 4.4 37 ± 5 -14.0 -26.3
1.03.01.01. Sialic acid-binding Ig-like lectin 5 SIGL5_HUMAN Homo sapiens Plasma memb. Out 436-464 (436-466) 40.0 ± 1.2 0 ± 1 -19.1 -51.9
1.03.01.01. Sialic acid-binding Ig-like lectin 6 SIGL6_HUMAN Homo sapiens Plasma memb. Out 352-374 (347-375) 27.2 ± 3.4 0 ± 1 -13.9 -39.5
1.03.01.01. Sialic acid-binding Ig-like lectin 7 SIGL7_HUMAN Homo sapiens Plasma memb. Out 357-379 (350-384) 37.6 ± 2.4 0 ± 0 -14.9 -39.1
1.03.01.01. Sialic acid-binding Ig-like lectin 8 SIGL8_HUMAN Homo sapiens Plasma memb. Out 365-387 (358-392) 38.8 ± 2.2 0 ± 0 -17.4 -40.0
1.03.01.01. Sialic acid-binding Ig-like lectin 9 SIGL9_HUMAN Homo sapiens Plasma memb. Out 352-373 (352-378) 27.6 ± 2.4 0 ± 0 -12.9 -30.0
1.03.01.01. Sialoadhesin SN_HUMAN Homo sapiens Plasma memb. Out 1639-1665 (1638-1669) 35.6 ± 2.8 24 ± 4 -22.7 -26.3
1.03.01.02. Nephrin NPHN_HUMAN Homo sapiens Plasma memb. Out 1059-1078 (1059-1079) 30.4 ± 2.7 16 ± 0 -7.2 -19.4
1.03.01.03. CXADR-like membrane protein CLMP_HUMAN Homo sapiens Plasma memb. Out 233-258 (225-262) 38.8 ± 1.6 1 ± 1 -24.0 -52.2
1.03.01.03. Coxsackievirus and adenovirus receptor CXAR_HUMAN Homo sapiens Plasma memb. Out 236-260 (232-267) 36.0 ± 4.4 7 ± 9 -22.5 -23.7
1.03.01.03. Endothelial cell-selective adhesion molecule ESAM_HUMAN Homo sapiens Plasma memb. Out 250-272 (247-274) 32.0 ± 1.4 0 ± 2 -16.5 -43.2
1.03.01.03. Cell surface A33 antigen GPA33_HUMAN Homo sapiens Plasma memb. Out 233-260 (231-264) 35.2 ± 3.2 0 ± 0 -19.5 -41.0
1.03.01.03. HEPACAM family member 2 HECA2_HUMAN Homo sapiens Golgi memb. Out 351-373 (351-375) 26.8 ± 4.0 0 ± 0 -17.3 -38.1
1.03.01.03. Hepatocyte cell adhesion molecule HECAM_HUMAN Homo sapiens Plasma memb. Out 241-265 (240-271) 31.6 ± 1.8 1 ± 1 -12.6 -41.3
1.03.01.03. Immunoglobulin superfamily member 11 IGS11_HUMAN Homo sapiens Plasma memb. Out 245-268 (240-271) 35.2 ± 4.4 2 ± 17 -23.2 -25.0
1.03.01.03. Junctional adhesion molecule A JAM1_HUMAN Homo sapiens Plasma memb. Out 235-261 (231-265) 40.0 ± 2.0 0 ± 3 -26.6 -53.2
1.03.01.03. Junctional adhesion molecule B JAM2_HUMAN Homo sapiens Plasma memb. Out 238-261 (237-264) 35.2 ± 2.0 0 ± 14 -18.2 -20.7
1.03.01.03. Junctional adhesion molecule C JAM3_HUMAN Homo sapiens Plasma memb. Out 242-267 (242-269) 33.6 ± 2.4 37 ± 5 -19.6 -23.8
1.03.01.03. Junctional adhesion molecule-like JAML1_HUMAN Homo sapiens Plasma memb. Out 274-299 (272-299) 32.8 ± 1.0 1 ± 2 -20.7 -41.5
1.03.01.03. V-set and immunoglobulin domain-containing protein 1 VSIG1_HUMAN Homo sapiens Plasma memb. Out 232-257 (231-263) 34.4 ± 1.2 0 ± 3 -15.4 -45.8
1.03.01.03. V-set and immunoglobulin domain-containing protein 2 VSIG2_HUMAN Homo sapiens Plasma memb. Out 242-266 (237-273) 38.4 ± 1.8 0 ± 1 -18.5 -49.9
1.03.01.03. V-set and immunoglobulin domain-containing protein 8 VSIG8_HUMAN Homo sapiens Plasma memb. Out 261-286 (257-288) 35.2 ± 2.2 2 ± 1 -15.1 -35.3
1.03.01.04. Myelin protein zero-like protein 1 MPZL1_HUMAN Homo sapiens Plasma memb. Out 162-190 (162-194) 36.8 ± 1.4 3 ± 3 -24.9 -47.4
1.03.01.04. Myelin protein zero-like protein 2 MPZL2_HUMAN Homo sapiens Plasma memb. Out 153-178 (149-181) 34.4 ± 2.6 28 ± 2 -27.1 -28.3
1.03.01.04. Myelin protein zero-like protein 3 MPZL3_HUMAN Homo sapiens Plasma memb. Out 155-181 (154-186) 38.0 ± 2.0 0 ± 2 -19.8 -56.1
1.03.01.04. Myelin protein P0 MYP0_HUMAN Homo sapiens Plasma memb. Out 154-180 (151-187) 35.6 ± 1.4 0 ± 0 -21.7 -55.0
1.03.01.04. Sodium channel subunit beta-2 SCN2B_HUMAN Homo sapiens Plasma memb. Out 158-183 (154-189) 34.8 ± 5.2 27 ± 2 -20.0 -23.3
1.03.01.04. Sodium channel subunit beta-4 SCN4B_HUMAN Homo sapiens Plasma memb. Out 162-191 (161-198) 39.6 ± 7.2 31 ± 1 -24.7 -32.9
1.03.01.05. Neural cell adhesion molecule L1-like protein CHL1_HUMAN Homo sapiens Plasma memb. Out 1081-1104 (1074-1107) 34.4 ± 3.8 3 ± 1 -21.8 -27.3
1.03.01.05. Neural cell adhesion molecule L1 L1CAM_HUMAN Homo sapiens Plasma memb. Out 1119-1144 (1118-1147) 33.2 ± 1.8 3 ± 1 -26.8 -42.3
1.03.01.05. Neurofascin NFASC_HUMAN Homo sapiens Plasma memb. Out 1214-1239 (1209-1242) 33.2 ± 4.6 3 ± 0 -26.1 -46.3
1.03.01.05. Neuronal cell adhesion molecule NRCAM_HUMAN Homo sapiens Plasma memb. Out 1168-1191 (1164-1194) 34.0 ± 3.0 5 ± 5 -24.7 -29.9
1.03.01.05. Neural cell adhesion molecule L1-like protein NCHL1_HUMAN Homo sapiens Plasma memb. Out 1081-1104 (1074-1107) 34.4 ± 3.8 3 ± 1 -21.8 -27.3
1.03.01.06. Protein turtle homolog A TUTLA_HUMAN Homo sapiens Plasma memb. Out 735-760 (734-767) 34.4 ± 3.4 22 ± 5 -13.5 -19.0
1.03.01.06. Protein turtle homolog B TUTLB_HUMAN Homo sapiens Plasma memb. Out 723-748 (723-754) 33.2 ± 3.2 37 ± 1 -21.0 -24.7
1.03.01.07. FRAS1-related extracellular matrix protein 2 FREM2_HUMAN Homo sapiens Plasma memb. Out 3107-3135 (3105-3139) 38.0 ± 4.8 22 ± 17 -14.6 -22.7
1.03.01.07. Extracellular matrix protein FRAS1 FRAS1_HUMAN Homo sapiens Plasma memb. Out 3898-3921 (3896-3924) 34.4 ± 2.8 0 ± 0 -23.0 -26.8
1.03.01.08. Kin of IRRE-like protein 1 KIRR1_HUMAN Homo sapiens Plasma memb. Out 500-522 (492-525) 38.0 ± 1.2 0 ± 1 -27.5 -60.4
1.03.01.08. Kin of IRRE-like protein 2 KIRR2_HUMAN Homo sapiens Plasma memb. Out 507-534 (507-539) 35.6 ± 5.0 29 ± 23 -15.8 -17.7
1.03.01.08. Kin of IRRE-like protein 3 KIRR3_HUMAN Homo sapiens Plasma memb. Out 532-559 (531-564) 40.4 ± 1.6 0 ± 0 -22.8 -51.8
1.03.01.09. Amphoterin-induced protein 1 AMGO1_HUMAN Homo sapiens Plasma memb. Out 372-394 (372-394) 27.2 ± 1.6 0 ± 0 -14.7 -37.6
1.03.01.09. Amphoterin-induced protein 2 AMGO2_HUMAN Homo sapiens Plasma memb. Out 396-420 (392-420) 33.6 ± 1.6 0 ± 0 -17.4 -46.2
1.03.01.09. Amphoterin-induced protein 3 AMGO3_HUMAN Homo sapiens Plasma memb. Out 381-404 (378-404) 30.8 ± 1.6 1 ± 0 -14.4 -47.3
1.03.01.10. Intercellular adhesion molecule 1 ICAM1_HUMAN Homo sapiens Plasma memb. Out 479-502 (477-507) 28.8 ± 1.8 7 ± 3 -18.8 -36.6
1.03.01.10. Intercellular adhesion molecule 2 ICAM2_HUMAN Homo sapiens Plasma memb. Out 221-249 (221-255) 35.6 ± 5.2 35 ± 6 -21.7 -27.1
1.03.01.10. Intercellular adhesion molecule 3 ICAM3_HUMAN Homo sapiens Plasma memb. Out 486-510 (486-516) 34.4 ± 1.8 30 ± 4 -22.4 -32.9
1.03.01.10. Intercellular adhesion molecule 4 ICAM4_HUMAN Homo sapiens Plasma memb. Out 241-268 (236-268) 34.0 ± 4.8 30 ± 14 -15.2 -16.5
1.03.01.10. Intercellular adhesion molecule 5 ICAM5_HUMAN Homo sapiens Plasma memb. Out 834-862 (834-866) 36.4 ± 4.8 29 ± 25 -11.1 -13.2
1.03.01.11. Cell adhesion molecule 1 CADM1_HUMAN Homo sapiens Plasma memb. Out 367-400 (365-402) 42.0 ± 2.6 1 ± 1 -23.1 -53.9
1.03.01.11. Cell adhesion molecule 2 CADM2_HUMAN Homo sapiens Plasma memb. Out 365-393 (365-395) 35.2 ± 1.6 0 ± 0 -18.6 -47.4
1.03.01.11. Cell adhesion molecule 3 CADM3_HUMAN Homo sapiens Plasma memb. Out 328-356 (325-358) 38.0 ± 1.6 0 ± 0 -31.9 -65.4
1.03.01.11. Cell adhesion molecule 4 CADM4_HUMAN Homo sapiens Plasma memb. Out 321-349 (320-352) 41.2 ± 1.6 0 ± 2 -23.0 -56.3
1.03.01.11. Cytotoxic and regulatory T-cell molecule CRTAM_HUMAN Homo sapiens Plasma memb. Out 284-312 (281-315) 36.8 ± 1.0 2 ± 1 -29.9 -56.0
1.03.01.11. Poliovirus receptor PVR_HUMAN Homo sapiens Plasma memb. Out 343-367 (342-370) 37.6 ± 2.2 1 ± 0 -25.0 -30.5
1.03.01.11. Poliovirus receptor-related protein 1 PVRL1_HUMAN Homo sapiens Plasma memb. Out 351-378 (351-382) 32.4 ± 1.2 1 ± 1 -16.8 -43.2
1.03.01.11. Poliovirus receptor-related protein 2 PVRL2_HUMAN Homo sapiens Plasma memb. Out 361-385 (361-386) 26.0 ± 2.0 0 ± 0 -15.2 -21.9
1.03.01.11. Poliovirus receptor-related protein 3 PVRL3_HUMAN Homo sapiens Plasma memb. Out 402-429 (400-432) 38.0 ± 1.4 2 ± 1 -22.9 -49.2
1.03.01.11. Poliovirus receptor-related protein 4 PVRL4_HUMAN Homo sapiens Plasma memb. Out 345-372 (345-378) 38.8 ± 1.6 0 ± 0 -28.7 -53.7
1.03.01.12. Neural cell adhesion molecule 1 NCAM1_HUMAN Homo sapiens Plasma memb. Out 721-746 (721-748) 36.8 ± 2.6 0 ± 0 -21.3 -46.5
1.03.01.12. Neural cell adhesion molecule 2 NCAM2_HUMAN Homo sapiens Plasma memb. Out 694-722 (694-722) 35.6 ± 3.4 31 ± 3 -16.1 -26.1
1.03.01.13. Transmembrane and immunoglobulin domain-containing protein 1 TMIG1_HUMAN Homo sapiens Plasma memb. Out 221-242 (221-247) 34.0 ± 2.8 15 ± 10 -14.5 -21.7
1.03.01.13. Transmembrane and immunoglobulin domain-containing protein 2 TMIG2_HUMAN Homo sapiens Plasma memb. Out 147-174 (147-176) 40.0 ± 2.8 1 ± 0 -16.6 -26.2
1.03.01.14. Vascular cell adhesion protein 1 VCAM1_HUMAN Homo sapiens Plasma memb. Out 697-720 (697-722) 30.4 ± 1.6 1 ± 0 -13.1 -27.5
1.03.01.15. Down syndrome cell adhesion molecule DSCAM_HUMAN Homo sapiens Plasma memb. Out 1595-1617 (1589-1626) 33.2 ± 0.6 0 ± 1 -25.7 -47.0
1.03.01.15. Down syndrome cell adhesion molecule-like protein 1 DSCL1_HUMAN Homo sapiens Plasma memb. Out 1588-1615 (1587-1624) 39.6 ± 4.4 5 ± 7 -18.8 -29.8
1.03.01.16. V-set and immunoglobulin domain-containing protein 10 VSI10_HUMAN Homo sapiens Plasma memb. Out 411-435 (411-437) 33.6 ± 4.0 22 ± 8 -15.7 -22.2
1.03.01.17. Protein sidekick-1 SDK1_HUMAN Homo sapiens Plasma memb. Out 2008-2033 (2005-2038) 36.0 ± 4.8 0 ± 8 -26.8 -29.2
1.03.01.17. Protein sidekick-2 SDK2_HUMAN Homo sapiens Plasma memb. Out 1926-1954 (1925-1961) 35.6 ± 4.8 29 ± 21 -31.2 -34.1
1.03.01.18. Matrix-remodeling-associated protein 7 MXRA7_HUMAN Homo sapiens Plasma memb. Out 4-26 (4-33) 34.2 ± 1.6 17 ± 12 -19.8 -24.5
1.03.01.18. Matrix-remodeling-associated protein 8 MXRA8_HUMAN Homo sapiens Vesicle memb. Out 338-363 (332-367) 30.4 ± 4.2 36 ± 5 -26.5 -30.7
1.03.01.19. Thy-1 membrane glycoprotein THY1_HUMAN Homo sapiens Plasma memb. Out 135-159 (135-160) 33.2 ± 3.4 22 ± 0 -8.5 -17.6
1.03.01.20. Basal cell adhesion molecule BCAM_HUMAN Homo sapiens Plasma memb. Out 544-572 (542-574) 36.0 ± 3.8 32 ± 5 -20.8 -28.5
1.03.01.20. CD166 antigen CD166_HUMAN Homo sapiens Plasma memb. Out 526-550 (524-558) 32.4 ± 4.2 33 ± 0 -23.8 -25.2
1.03.01.20. Cell surface glycoprotein MUC18 MUC18_HUMAN Homo sapiens Plasma memb. Out 555-583 (555-585) 34.4 ± 3.2 41 ± 0 -25.3 -29.9
1.03.01.20. T-cell surface protein tactile TACT_HUMAN Homo sapiens Plasma memb. Out 521-542 (521-553) 33.6 ± 2.0 0 ± 2 -17.6 -37.5
1.03.01.21. CD226 antigen CD226_HUMAN Homo sapiens Plasma memb. Out 251-276 (246-282) 34.4 ± 2.2 29 ± 0 -27.1 -31.3
1.03.01.22. Mucosal addressin cell adhesion molecule 1 MADCA_HUMAN Homo sapiens Plasma memb. Out 321-343 (319-346) 28.0 ± 2.2 0 ± 0 -14.3 -29.6
1.03.01.23. Microfibrillar-associated protein 3-like MFA3L_HUMAN Homo sapiens Plasma memb. Out 151-172 (151-175) 32.0 ± 3.4 16 ± 7 -15.8 -19.4
1.03.01.23. Microfibril-associated glycoprotein 3 MFAP3_HUMAN Homo sapiens Plasma memb. Out 149-170 (146-173) 32.8 ± 2.6 0 ± 0 -16.3 -19.0
1.03.01.24. Immunoglobulin superfamily member 5 IGSF5_HUMAN Homo sapiens Plasma memb. Out 266-287 (266-292) 32.8 ± 3.0 2 ± 1 -3.4 -13.7
1.03.01.25. Platelet endothelial cell adhesion molecule PECA1_HUMAN Homo sapiens Plasma memb. Out 599-625 (597-630) 38.0 ± 5.0 9 ± 12 -23.2 -28.1