1.09.18.03. Cytochrome P450, E-class, group IV - IPR002403 (InterPro) (23 proteins)

Protein Name Protein ID Species Localization Topology TM Segment (helix) Hydrophobic Thickness (Å) Tilt Angle (°) ΔGfold (kcal/mol) ΔGtransf (kcal/mol)
24-hydroxycholesterol 7-alpha-hydroxylase CP39A_HUMAN Homo sapiens ER memb. Out 2-23 (2-27) 34.6 ± 2.6 19 ± 15 -14.7 -22.2
25-hydroxycholesterol 7-alpha-hydroxylase CP7B1_HUMAN Homo sapiens ER memb. Out 14-38 (13-42) 37.2 ± 3.6 0 ± 3 -18.5 -27.4
3-epi-6-deoxocathasterone 23-monooxygenase C90C1_ARATH Arabidopsis thaliana ER memb. Out 25-45 (22-51) 30.8 ± 2.6 2 ± 13 -12.9 -22.5
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase CP8B1_HUMAN Homo sapiens ER memb. Out 4-25 (4-29) 30.0 ± 4.0 17 ± 9 -8.5 -18.5
At1g47620 Q9SX95_ARATH Arabidopsis thaliana ER memb. Out 6-26 (6-26) 30.0 ± 2.7 15 ± 3 -9.9 -17.4
Cholesterol 7-alpha-monooxygenase CP7A1_HUMAN Homo sapiens ER memb. Out 4-24 (4-27) 30.4 ± 3.1 1 ± 2 -12.8 -16.0
Cytochrome P450 26A1 CP26A_HUMAN Homo sapiens ER memb. Out 3-31 (3-31) 31.2 ± 2.8 37 ± 1 -20.0 -26.8
Cytochrome P450 26B1 CP26B_HUMAN Homo sapiens ER memb. Out 8-32 (8-41) 30.0 ± 2.6 34 ± 2 -17.1 -20.9
Cytochrome P450 26C1 CP26C_HUMAN Homo sapiens ER memb. Out 8-30 (6-41) 34.2 ± 3.5 4 ± 7 -14.2 -14.8
Cytochrome P450 61 ERG5_YEAST Saccharomyces cerevisiae ER memb. Out 45-64 (43-68) 29.4 ± 2.5 1 ± 18 -12.8 -18.2
Cytochrome P450 708A2 THAH_ARATH Arabidopsis thaliana ER memb. Out 3-24 (3-27) 31.0 ± 2.1 28 ± 0 -15.0 -21.7
Cytochrome P450 85A1 C85A1_ARATH Arabidopsis thaliana ER memb. Out 3-24 (3-32) 32.6 ± 4.0 30 ± 1 -18.7 -22.2
Cytochrome P450 family protein F4J4C0_ARATH Arabidopsis thaliana ER memb. Out 3-24 (3-27) 29.8 ± 2.7 42 ± 7 -5.5 -20.0
Cytochrome P450 superfamily protein F4HQ70_ARATH Arabidopsis thaliana ER memb. Out 14-34 (7-39) 31.6 ± 3.7 1 ± 7 -20.4 -24.2
Cytochrome P450, family 702, subfamily A, polypeptide 3 F4JJG4_ARATH Arabidopsis thaliana ER memb. Out 3-25 (3-28) 32.0 ± 2.0 35 ± 0 -12.0 -21.9
Cytochrome P450, family 702, subfamily A, polypeptide 5 A8MS53_ARATH Arabidopsis thaliana ER memb. Out 4-27 (4-27) 31.6 ± 2.6 26 ± 0 -9.0 -18.2
Cytochrome P450, family 702, subfamily A, polypeptide 6 F4JK32_ARATH Arabidopsis thaliana ER memb. Out 4-23 (4-24) 26.8 ± 2.0 16 ± 9 -7.3 -16.0
Lanosterol 14-alpha demethylase CP51A_HUMAN Homo sapiens ER memb. Out 26-47 (26-48) 32.0 ± 1.8 16 ± 6 -15.4 -20.2
Lanosterol 14-alpha demethylase CP51_YEAST Saccharomyces cerevisiae ER memb. Out 27-48 (27-54) 28.8 ± 2.1 29 ± 1 -9.7 -19.4
Probable lanosterol 14-alpha demethylase CP51_DICDI Dictyostelium discoideum ER memb. Out 2-20 (1-21) 32.4 ± 3.4 2 ± 14 -16.3 -24.2
Prostacyclin synthase PTGIS_HUMAN Homo sapiens ER memb. Out 2-21 (1-25) 32.8 ± 2.8 3 ± 2 -19.8 -23.4
Putative sterol 14-demethylase-like protein CP512_ARATH Arabidopsis thaliana ER memb. Out 7-28 (3-32) 30.4 ± 3.5 5 ± 12 -18.2 -23.6
Sterol 14-demethylase CP511_ARATH Arabidopsis thaliana ER memb. Out 8-31 (5-37) 32.4 ± 1.8 30 ± 0 -15.9 -28.5