1.09.20.01. Short-chain dehydrogenases/reductases - IPR002198 (InterPro) (24 proteins)

Protein Name Protein ID Species Localization Topology TM Segment (helix) Hydrophobic Thickness (Å) Tilt Angle (°) ΔGfold (kcal/mol) ΔGtransf (kcal/mol)
3-keto-steroid reductase DHB7_HUMAN Homo sapiens ER memb. Out 230-254 (229-256) 35.6 ± 4.0 4 ± 4 -11.5 -27.4
3-keto-steroid reductase ERG27_YEAST Saccharomyces cerevisiae ER memb. Out 242-262 (240-262) 29.0 ± 3.2 6 ± 3 -6.6 -16.0
3-ketodihydrosphingosine reductase TSC10 TSC10_YEAST Saccharomyces cerevisiae ER memb. Out 280-305 (280-308) 32.4 ± 3.2 30 ± 2 -3.5 -18.5
At5g04070 Q6NLR7_ARATH Arabidopsis thaliana Membrane In 15-34 (13-38) 28.2 ± 2.8 6 ± 5 -9.6 -17.4
Corticosteroid 11-beta-dehydrogenase isozyme 1 DHI1_HUMAN Homo sapiens ER memb. In 2-21 (2-24) 24.8 ± 2.6 0 ± 0 -3.5 -16.4
Dehydrogenase/reductase SDR family member 7B DRS7B_HUMAN Homo sapiens ER memb. In 18-43 (18-47) 32.8 ± 3.6 30 ± 2 -12.5 -24.4
Dehydrogenase/reductase SDR family member 7C DRS7C_HUMAN Homo sapiens Membrane In 3-25 (3-27) 33.0 ± 2.7 4 ± 15 -15.6 -24.8
Dehydrogenase/reductase SDR family protein 7-like DHRS7_DICDI Dictyostelium discoideum Peroxisome memb. In 12-34 (12-35) 27.8 ± 2.8 37 ± 3 -9.9 -20.7
Estradiol 17-beta-dehydrogenase 2 DHB2_HUMAN Homo sapiens ER memb. In 54-72 (54-80) 28.4 ± 1.8 17 ± 0 -9.6 -18.0
Probable oxidoreductase ENV9 ENV9_YEAST Saccharomyces cerevisiae Lipid droplet Und 241-264 (239-266) 30.8 ± 1.6 31 ± 0 -11.0 -26.1
Rossmann-fold NAD(P)-binding domain-containing protein F4KBA8_ARATH Arabidopsis thaliana Membrane In 15-33 (13-38) 26.8 ± 2.7 10 ± 1 -7.3 -14.1
Short-chain dehydrogenase/reductase 3 DHRS3_HUMAN Homo sapiens Membrane In 8-34 (8-38) 34.2 ± 2.8 41 ± 8 -5.6 -23.9
Testosterone 17-beta-dehydrogenase 3 DHB3_HUMAN Homo sapiens ER memb. In 4-26 (3-28) 30.4 ± 3.2 27 ± 3 -10.0 -21.7
Uncharacterized oxidoreductase YNL181W YNS1_YEAST Saccharomyces cerevisiae ER memb. Out 292-313 (292-317) 32.2 ± 2.5 4 ± 0 -14.3 -21.5
Uncharacterized protein Q54Q56_DICDI Dictyostelium discoideum Membrane In 2-22 (2-22) 30.6 ± 2.8 1 ± 1 -10.9 -21.3
Uncharacterized protein Q54I21_DICDI Dictyostelium discoideum Membrane In 13-37 (12-42) 33.6 ± 3.6 4 ± 4 -15.8 -20.2
Uncharacterized protein Q55CK8_DICDI Dictyostelium discoideum Membrane Out 256-281 (256-285) 31.6 ± 1.4 38 ± 5 -9.4 -22.1
Uncharacterized protein Q54I23_DICDI Dictyostelium discoideum Membrane In 9-34 (9-39) 32.4 ± 4.6 32 ± 0 -14.4 -27.4
Uncharacterized protein Q75JE7_DICDI Dictyostelium discoideum Membrane In 9-31 (6-36) 32.2 ± 1.9 7 ± 3 -16.0 -19.9
Uncharacterized protein Q54NY5_DICDI Dictyostelium discoideum Membrane In 2-24 (2-24) 34.4 ± 2.9 30 ± 28 -19.2 -24.7
Uncharacterized protein Q75JC5_DICDI Dictyostelium discoideum Membrane In 9-31 (6-36) 31.4 ± 2.2 12 ± 2 -15.3 -19.9
Uncharacterized protein Q54CD7_DICDI Dictyostelium discoideum Membrane In 5-31 (2-33) 30.8 ± 4.6 41 ± 5 -15.7 -23.8
Very-long-chain 3-oxoacyl-CoA reductase DHB12_HUMAN Homo sapiens ER memb. In 4-26 (4-28) 34.8 ± 1.7 0 ± 5 -6.2 -13.3
Very-long-chain 3-oxoacyl-CoA reductase MKAR_YEAST Saccharomyces cerevisiae ER memb. In 34-56 (34-60) 32.2 ± 2.7 2 ± 2 -7.5 -22.1