Membranome database


See all membrane protein images in Membranome

Membranome database provides structural and functional data about single-spanning (bitopic) transmembrane proteins of six organisms (human, thale cress flowering plant, slim mold, baker's yeast, gut eubacteria, thermophilic methanogenic archaeabacteria) representing all kingdoms of life.

It includes evolutionary classification, topology and intracellular localization of bitopic proteins, protein-protein interactions and known protein complexes, links to three-dimensional structures and metabolic pathways, and our computationally generated models of transmembrane domains optimized in the lipid bilayer.

In citing the Membranome database please refer to
Lomize AL, Lomize MA, Krolicki SR, Pogozheva ID (2016) Membranome: a database for proteome-wide analysis of single-pass membrane proteins. Nucleic Acids Res. pii: gkw712. (PubMed)

For an explanation of the TMDOCK method please refer to
Lomize AL, Pogozheva ID (2016) TMDOCK: an energy-based method for modeling alpha-helical dimers in membranes. J Mol Biol. pii: S0022-2836(16)30369-2. (PubMed)

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Membranome is funded by the National Science Foundation (NSF) NSF